Bias in decisions made by modern software is becoming a common and serious problem. We present Themis, an automated test suite generator to measure two types of discrimination, including causal relationships between sensitive inputs and program behavior. We explain how Themis can measure discrimination and aid its debugging, describe a set of optimizations Themis uses to reduce test suite size, and demonstrate Themis' effectiveness on open-source software. Themis is open-source and all our evaluation data are available at http://fairness.cs.umass.edu/. See a video of Themis in action: https://youtu.be/brB8wkaUesY CCS CONCEPTS• Software and its engineering → Software testing and debugging;
Some approaches have been used to investigate evidence on how developers refactor their code, whether refactorings activities may decrease the number of bugs, or improve developers' productivity. However, there are some contradicting evidence in previous studies. For instance, some investigations found evidence that if the number of refactoring changes increases in the preceding time period the number of defects decreases, different from other studies. They have used different approaches to evaluate refactoring activities. Some of them identify committed behavior-preserving transformations in software repositories by using manual analysis, commit messages, or dynamic analysis. Others focus on identifying which refactorings are applied between two programs by using manual inspection or static analysis. In this work, we compare three different approaches based on manual analysis, commit message (Ratzinger's approach) and dynamic analysis (SafeRefactor's approach) to detect whether a pair of versions determines a refactoring, in terms of behavioral preservation. Additionally, we compare two approaches (manual analysis and Ref-Finder) to identify which refactorings are performed in each pair of versions. We perform both comparisons by evaluating their accuracy, precision, and recall in a randomly selected sample of 40 pairs of versions of JHotDraw, and 20 pairs of versions of Apache Common Collections. While the manual analysis presents the * Corresponding author Email addresses: gsoares@dsc.ufcg.edu.br (Gustavo Soares), rohit@dsc.ufcg.edu.br (Rohit Gheyi), emerson@csc.ncsu.edu (Emerson Murphy-Hill), bijohnso@csc.ncsu.edu (Brittany Johnson) Preprint submitted to Journal of Systems and Software November 6, 2012 best results in both comparisons, it is not as scalable as the automated approaches. Ratzinger's approach is simple and fast, but presents a low recall; differently, SafeRefactor is able to detect most applied refactorings, although limitations in its test generation backend results for some kinds of subjects in low precision values. Ref-Finder presented a low precision and recall in our evaluation.
Objective: Recent literature suggests that intravenous (IV) administration may cause hypotension in hospitalized patients; data further suggest that this effect is most pronounced in the critically ill. The purpose of this review is to identify and evaluate current literature that addresses the incidence and implications of IV acetaminophen–induced hypotension. Data Sources: A literature search of MEDLINE, Cochrane, and EMBASE databases was performed (2002-2019) using the following terms: acetaminophen, paracetamol, intravenous, and hypotension. Abstracts and peer-reviewed publications were reviewed. Study Selection and Data Extraction: Relevant English-language studies conducted in humans evaluating the hemodynamic effects of IV acetaminophen were considered. Data Synthesis: A majority of the 19 studies included in this review identified a statistically significant drop in hemodynamic variables after the administration of 500 to 1000 mg IV acetaminophen as measured by changes in systolic blood pressure, diastolic blood pressure, or mean arterial pressure. Of the trials reporting vasopressor use, the authors found a significant increase in vasopressor requirements following IV acetaminophen administration. Relevance to Patient Care and Clinical Practice: This review represents the first comprehensive review of IV acetaminophen-induced hypotension. The findings raise the question of whether IV acetaminophen is an appropriate choice for inpatient pain or temperature management in the critically ill. Conclusions: Available evidence indicates that the administration of IV acetaminophen may be harmful in the critically ill. Additional monitoring is likely required when using IV acetaminophen in this specific population, particularly if a patient is hemodynamically unstable prior to administration.
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