In this study, we designed two deep neural networks to encode 16 features for early seizure detection in intracranial EEG and compared them and their frequency responses to 16 widely used engineered metrics to interpret their properties: epileptogenicity index (EI), phase locked high gamma (PLHG), time and frequency domain Cho Gaines distance (TDCG, FDCG), relative band powers, and log absolute band powers (from alpha, beta, theta, delta, low gamma, and high gamma bands). The deep learning models were pretrained for seizure identification on the time and frequency domains of 1 s, single-channel clips of 127 seizures (from 25 different subjects) using “leave-one-out” (LOO) cross validation. Each neural network extracted unique feature spaces that were interpreted using spectral power modulations before being used to train a Random Forest Classifier (RFC) for seizure identification. The Gini Importance of each feature was calculated from the pretrained RFC, enabling the most significant features (MSFs) for each task to be identified. The MSFs were extracted to train another RFC for UPenn and Mayo Clinic’s Seizure Detection Kaggle Challenge. They obtained an AUC score of 0.93, demonstrating a transferable method to identify and interpret biomarkers for seizure detection.
In this study we designed two deep neural networks to encode 16 feature latent spaces for early seizure detection in intracranial EEG and compared them to 16 widely used engineered metrics: Epileptogenicity Index (EI), Phase Locked High Gamma (PLHG), Time and Frequency Domain Cho Gaines Distance (TDCG, FDCG), relative band powers, and log absolute band powers (from alpha, beta, theta, delta, gamma, and high gamma bands. The deep learning models were pretrained for seizure identification on the time and frequency domains of one second single channel clips of 127 seizures (from 25 different subjects) using “leave-one-out” (LOO) cross validation. Each neural network extracted unique feature spaces that were used to train a Random Forest Classifier (RFC) for seizure identification and latency tasks. The Gini Importance of each feature was calculated from the pretrained RFC, enabling the most significant features (MSFs) for each task to be identified. The MSFs were extracted from the UPenn and Mayo Clinic's Seizure Detection Challenge to train another RFC for the contest. They obtained an AUC score of 0.93, demonstrating a transferable method to identify interpretable biomarkers for seizure detection.
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