Heterotopic pregnancy is defined as a condition when intrauterine and extrauterine pregnancy occur simultaneously. It is a life-threatening condition that requires immediate and accurate diagnostics and treatment. We present a case of a 28-year-old primigravida female who conceived spontaneously and at her seventh week of gestation and was presented to the emergency department with weakness and acute pain in lower abdomen. Laboratory tests and transvaginal ultrasonography revealed the diagnosis of heterotopic pregnancy. Urgent laparoscopic salpingotomy was chosen as a treatment option. The ectopic pregnancy was successfully removed with the preservation of the intrauterine embryo and fallopian tubes. The course of pregnancy after the surgery was without complications, and a healthy baby was delivered at the 39th week of gestation. When treated properly and on time, a heterotopic pregnancy can result in live childbirth with favorable outcomes for both the child and the mother.
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Abstract
Objectives: The aim of the study was to identify and evaluate a possible correlation between C-reactive protein (CRP) concentration in maternal blood and the risk of developing fetal inflammatory syndrome (FIRS).
Material and methods: The study included 158 infants born at 22-34 weeks of gestation and their mothers. Umbilical cord blood cytokines were evaluated in immunoassay tests and maternal blood was tested for CRP concentration.Results: The period of gestation was significantly shorter in the FIRS group as compared to the control group (29.5±3.1 vs. 32.2±2.4 weeks, p<0.
001). Gestational age was ≤30 weeks for 53.8% of the newborns in the FIRS group and 15.8% of the newborns in the control group (p<0.001). Maternal CRP before, during and after labor was significantly higher in the FIRS group as compared to the control group (p<0.001). Our study investigated the correlation between CRP in maternal blood and IL-6 concentration during the entire perinatal period (p<0.001).
Conclusion: CRP concentration in the FIRS group was significantly higher than in controls before
Objective The aim was to identify the critical levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor-A in umbilical cord blood that could be used as markers for predicting the central nervous system (CNS) damage and retinopathy of prematurity (ROP) in preterm infants.
Study Design A total of 158 preterm infants, born at 22 to 34 weeks of gestation, were evaluated in the first week after birth and at 36 to 37 weeks of postconceptual age.
Results A significant relationship between CNS changes and concentrations of IL-6 (p < 0.001) and TNF-α (p < 0.001) in umbilical cord blood at 22 to 34 weeks of gestation was determined. The concentration of IL-6 >13.0 pg/mL predicts significant CNS damages in 36 to 37-week infants (p = 0.013). ROP was diagnosed in 24.8% infants (n = 149). It was detected that the levels of TNF-α >116.4 pg/mL (p < 0.001) and IL-6 >13.0 pg/mL (p < 0.05) in umbilical cord blood could predict 2 to 3/3 to 4 stages of ROP.
Conclusion Critical values of IL-6 and TNF-α in predicting ≥grade III intraventricular hemorrhage in the early adaptation and in predicting marked CNS damages and severe ROP stages in the later adaptation of preterm infants were determined.
Šioje literatūros apžvalgoje įvertinta sudėtinių kontraceptinių tablečių (SKT) įtaka emocinei sveikatai skirtingose moterų amžiaus grupėse: paauglių (10–18 metų), jaunų moterų (19–35 metų). Taip pat aprašytas SKT poveikis moterims, vartojančioms kontraceptines tabletes pirmaisiais metais po gimdymo, pateikiami galimi sąveikos tarp SKT ir depresijos išsivystymo mechanizmai, geriamųjų kontraceptikų poveikio emocinei sveikatai ryšys su ankstesniais depresinio pobūdžio sveikatos sutrikimais. „PubMed“ duomenų bazėje ieškota straipsnių apie SKT įtaką depresinių simptomų pasireiškimui, depresijos išsivystymui, emocinės būklės pablogėjimui. Tarp paauglių SKT vartojimas susijęs su depresinių sutrikimų, savižudybės rizika, anksčiau pradedamu gydymu antidepresantais. Moterims nuo 19 iki 35 metų amžiaus SKT įtaka emocinei sveikatai priklauso nuo SKT sudėties. SKT sudėtyje esantys progestinai: noretisteronas, levonorgestrelis arba desogestrelis mažina, o linestrenolis arba drospirenonas didina depresinių sutrikimų riziką. Taigi, geriamieji kontraceptikai turi įtakos moters psichoemocinei sveikatai. Vis dėlto SKT skirti saugu prieš tai surinkus išsamią pacientės anamnezę ir parenkant tinkamą SKT sudėtį.
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