Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The crystal structure of the ligand has been determined by single crystal X-ray diffraction and electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b = 7.86555(14) Å, c = 16.1614(3) Å, V = 2298.60(7) Å3, Z = 8, T = 103 K, μ(Mo Kα) = 0.093 mm-1, Dcalc = 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ ≤ 54.966°), 2633 unique (Rint = 0.0224, Rsigma = 0.0124) which were used in all calculations. The final R1 was 0.0383 (F2>2σ(F2)) and wR2 was 0.0988 (all data). The ligand was found to chelate to the metal ions through the azomethine nitrogen and amide oxygen atoms in a bidentate manner. The anti-tubercular activity of the ligand, its iron (II) and manganese (II) complexes were studied against Mycobacterium tuberculosis (ATTC 27294). The results revealed higher activity of the iron (II) complex with MIC value of 8.00±0.83 µM and a moderate activity of the manganese (II) complex having MIC value of 14.20±1.40 µM, compared to the reference drugs having MIC values of 9.41±0.92, 10.74±1.02, 25.34±2.6 µM and parent ligand with MIC value of 17.60±1.80 µM.
A new copper(I) pyrazine-bridged coordination polymer [Cu2(pyz)3(NO3)2]·2DMF] (pyz = pyrazine) (1) has been synthesized and characterized by FT-IR, TG/DTG, DSC and single crystal X-ray diffraction techniques. The X-ray crystallographic result reveals a two-dimensional network structure containing hexagonal pores. Thermal analysis of compound 1 reveals it is stable to 380 °C, and gas sorption studies showed that it adsorbs 1.04 wt% hydrogen at 1 atm and 77 K. Compound 1 crystallizes in a triclinic system, space group P-1 (no. 2), a = 7.9550(2) Å, b = 7.9810(2) Å, c = 11.0660(3) Å, α = 76.328(1)°, β = 71.115(1)°, γ = 84.577(1)°, V = 645.79(3) Å3, Z = 2, T = 150(2) K, μ(MoKα) = 1.709 mm-1, Dcalc = 1.639 g/cm3, 11111 reflections measured (7° ≤ 2Θ ≤ 54.96°), 2951 unique (Rint = 0.0539) which were used in all calculations. The final R1 was 0.0346 (>2σ(I)) and wR2 was 0.0727 (all data).
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