In experienced hands, EVH is associated with a significant decrease in wound complications with similar graft patency, reintervention rates, and limb salvage.
Myotonic dystrophy is associated with progressive muscular atrophy. To define the mechanism of muscle wasting in this disease, we studied myofibrillar proteolysis in vivo in 8 men moderately affected with myotonic dystrophy, and compared the results with those of 10 normal men. Myofibrillar proteolysis was estimated by measuring the 3-methylhistidine arteriovenous difference (A-V) and efflux (Q) across the forearm in the postabsorptive state. Plasma 3-methylhistidine concentrations were determined by high-performance liquid chromatography with postcolumn o-phthalaldehyde derivatization and fluorescence detection. Plasma flow to the forearm muscles (F) was estimated to represent 85% of total forearm plasma flow as determined by the indicator-dilution technique. Forearm 3-methylhistidine efflux was calculated as: Q = F(A-V). Mean muscle mass (24-hour creatinine excretion), lean body mass, and forearm volume were decreased in the patients with myotonic dystrophy, confirming the presence of muscle atrophy. Mean forearm 3-methylhistidine arteriovenous difference and efflux were not significantly different in the two groups. We conclude that myofibrillar protein degradation is not increased in myotonic dystrophy, even when measured in a muscle compartment selectively affected by wasting. Muscle atrophy in myotonic dystrophy is probably the result of defective anabolism rather than accelerated catabolism.
Objectives: Iliac vein stenting of nonthrombotic iliac vein lesions (NIVL) is becoming a common treatment option for venous insufficiency. This treatment option helps relieve symptoms of venous insufficiency that is derived from venous reflux. We examined the effect that iliac vein stenting had on reflux times before and after stenting. Methods: Over the course of 22 months, we performed 655 venograms with angioplasties and stenting of the iliac veins. These procedures were filtered to only include the venograms where a stent was placed, and no other vascular procedures was performed between "pre" and "post" venous mapping tests. This was done to ensure that the iliac vein stent placed was the only procedure affecting the venous reflux. This left 273 procedures performed over the course of 14 months. Reflux was measured using ipsilateral ultrasound. Results: The patients were an average age of 70.44 years (standard deviation, 14.12; range, 23-95 years), with 177 women and 96 men. The CEAP scores were C 2 in 11%, C 3 in 53%, C 4 in 11%, C 5 in 3%, and C 6 in 22%. Table reports the average reflux values before and after stenting and the tendency of the decrease in reflux. Conclusions: These data reveal a uniform decrease in the vein reflux of prestent and poststent reflux values. However, no statistical significance was calculated between the prestent and poststent average reflux time, probably due to the large standard deviation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.