Spectrophotometric observations of solutions consisting initially of thiol and iodine in acetic acid, or of disulfide and hydrogen iodide in acetic acid, give evidence that this is an equilibrating system which probably involves three reactions (eq 3-5). Practical difficulties prevented the determination of the value for the equilibrium constant for the overall system, but the equilibrium constant for reaction 5 in AcOH has been found to be 1.1 (±0.1) X 106. Studies on the titration of 3-mercaptopropionic acid with iodine in acetic acid containing increasing amounts of water or anhydrous sodium acetate show that displacement of the equilibrium toward the disulfide side depends on the equilibrating reaction between hydrogen iodide and base.
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