Background: In this study, best corrected visual acuity and macular thickness were compared before and after
intravitreal injection Ranibizumab monotherapy and combined therapy of injection Ranibizumab and laser, in patients
with macular oedema ≥350µm measured with spectral domain OCT. Objective:Our specific objective is to identify the
best treatment option in NPDR with macular thickness ≥350µm in Type 2 diabetic retinopathy patients depending upon
the anatomical and functional outcome in each group. Method: Sixty (60) newly diagnosed eyes of NPDR with macular
oedema (30 patients in each group) attending retina research clinic of Regional Institute of Ophthalmology,Kolkata were
included in this study. Result: This parallel group comparison trial has shown that a combination of 3 consecutive
monthly doses of intravitreal ranibizumab followed by modified grid laser therapy 7-10 days latter is more effective in
reducing central macular thickness in comparison to only multiple injections of ranibizumab,but there is no difference in
the final best corrected visual acuity attained in between the two groups. Conclusion: Laser photocoagulation along
withanti-vascularendothelialgrowthfactoragentisthestrongerweapontofightagainstblindnessindiabeticmacularedema
Purpose:To determine the prevalence of advanced diabetic eye disease (ADED ) in patients with type 2 diabetes mellitus (DM) attending a tertiary
eye care centre in eastern India and the risk factors associated with the disease.
Methods: All patients of type 2 DM attending at the out-patient-department of a tertiary eye care centre, with any stage of diabetic retinopathy
(DR) were recruited for this study. Examination was carried out with the help of slit-lamp biomicroscope with +90D lens, direct and indirect
ophthalmoscopy, Snellen's chart, refraction trial lens and B-scan Ultrasonography. Medical records were reviewed and data were extracted.
Results: Out of 200 patients with DR, 22 patients presented with advanced diabetic eye disease (ADED). Thus, the prevalence of ADED in this
study was 11%. Those with increased age of presentation, long duration of DM, deranged HbA1c and lipid prole are at signicantly higher risk of
presenting with ADED.
Conclusion: Prevalence of 11 % of ADED in patients with DM attending a tertiary eye care centre shows that this condition continues to be a major
social problem despite current knowledge about advanced DR.
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