This paper presents the results of an investigation using a new instrument for the study of brain damage in human subjects. The design of the instrument, the Continuous Performance Test (CPT) was based on certain electroencephalographic evidence which suggested that brain-damaged individuals should show inferior ability as compared with non-brain-damaged individuals on tasks requiring sustained attention or alertness.The waking EEGs of brain-damaged patients generally show either random bursts of hypersynchronous (high amplitude) activity intruding upon the normal activity of the brain, or a general hypersynchrony (3, 8). Hypersynchronous activity is also evident in 1 The authors would like to extend their appreciation to the following individuals and institutions for providing advice and/or subjects and testing facilities for this research: Mr. Samuel Greenhouse of the
The combination of alpha-metyrosine and alpha-blockade results in better blood pressure control and less need for use of antihypertensive medication or pressors during surgery, compared with the classical method of single-agent adrenergic blockade. Preoperative treatment with metyrosine along with an alpha-blocker is a useful strategy for decreasing the surgical morbidity in patients with pheochromocytoma and assumes greater importance as long as the availability of phentolamine for intraoperative use is a problem.
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