Background: Experimental and clinical evidence suggest that hypoxia in solid tumours reduces their sensitivity to conventional treatment modalities modulating response to ionizing radiation or chemotherapeutic agents. The aim of the present study was to show the feasibility of determining radiotherapeutically relevant hypoxia and early tumour response by ([ 18 F] Fluoromisonidazole (FMISO) and [ 18 F]-2-fluoro-2'-deoxyglucose (FDG) PET.

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Background: The present study was conducted to analyze the value of ([ 18 F] fluoromisonidazole (FMISO) and [ 18 F]-2-fluoro-2'-deoxyglucose (FDG) PET as well as color pixel density (CPD) and tumor perfusion (TP) assessed by color duplex sonography (CDS) for determination of therapeutic relevant hypoxia. As a standard for measuring tissue oxygenation in human tumors, the invasive, computerized polarographic needle electrode system (pO 2 histography) was used for comparing the different non invasive measurements.