Objective-Previous studies suggest mindfulness is associated with pain and depression. However, its impact in individuals with fibromyalgia remains unclear. We examined associations between mindfulness and physical and psychological symptoms, pain interference, and quality of life in fibromyalgia patients.Methods-We performed a cross-sectional analysis on baseline data from a fibromyalgia clinical trial. Mindfulness was assessed using the Five Facet Mindfulness Questionnaire (FFMQ). Pearson's correlations and multivariable linear regression models were used to evaluate associations between mindfulness and fibromyalgia impact, pain interference, physical function, depression, anxiety, stress, self-efficacy, and health-related quality of life. We also examined whether mindfulness moderated associations between fibromyalgia impact and psychological outcomes.Results-A total of 177 participants (age 52.0±12.2 (SD) years; 93.2% women; 58.8% white; body mass index 30.1±6.7 kg/m 2 ; FFMQ score 131.3±20.7; Revised Fibromyalgia Impact Questionnaire score 57.0±19.4) were included. Higher total mindfulness was significantly associated with lower fibromyalgia impact (r=−0.25), pain interference (r=−0.31), stress