Risk, III.

This study provides evidence that obesity increases the risk of complications in both implant-based and autologous reconstruction. Additional prospective and observational studies are needed to determine if the weight reduction prior to reconstruction reduces the perioperative risks associated with obesity.

No abstract

: Therapeutic, III.

Prognostic/risk, level III.

Risk, II.

INTRODUCTION: The use of postmastectomy radiation therapy (PMRT) has been widely accepted for patients with 4 or more positive lymph nodes; however, its role in patients with 1-3 positive lymph nodes remains unclear. The purpose of this study is to evaluate the oncological outcomes after undergoing PMRT for breast cancer patients with a T1-2 tumors and 1-3 positive lymph nodes. METHODS: We performed a single-institution retrospective investigation that compared PMRT and outcomes in breast cancer patients with T1-2 tumors and 1-3 positive lymph nodes who underwent mastectomy from 2002 to 2015. Multivariable Cox proportional hazards regression was used to evaluate the association of PMRT with loco-regional recurrence (LRR), distant metastasis, disease-free survival, and overall survival. RESULTS: A total of 403 patients met inclusion criteria, of which 207 (51%) received PMRT while 201 (49%) did not receive PMRT after mastectomy and were followed over a median of 5.3 years. Outcomes in patients were similar by PMRT status: LRR (2 vs 0, p ¼ 0.242); distant metastasis (6 vs 7, p ¼ 0.820). After adjustment for potential confounding variables, PMRT was not associated with any cancer recurrence (hazard ratio [HR]: 1.

Prognostic/risk category, level III.