Our results suggest that use of high-dose TXA in older patients in conjunction with cardiopulmonary bypass and open-chamber cardiac surgery is associated with clinical seizures in susceptible patients.

Twenty-one years ago, Ericsson, Krampe and Tesch-Romer published their seminal work expounding the notion of deliberate practice in explaining the development of expertise. This concept has since become extremely influential in the fields of sport psychology and motor learning. This review evaluates current understanding of deliberate practice in sport skill acquisition with an emphasis on the role of deliberate practice in distinguishing expert athletes from non-experts. In particular, we re-examine the original tenets of Ericsson et al.'s framework to (a) evaluate the sport-related research supporting their claims and (b) identify remaining research questions in this area. The review highlights the overall importance of deliberate practice in the development of expert sport performers; however, our understanding is far from complete. Several directions for future research are highlighted, including the need for more rigorous research designs and statistical models that can evaluate changes in developmental and contextual factors across development. Finally, we advocate for a more thorough understanding of the implications of a 'deliberate practice approach' for coaching science.

Loss of motor responses better than extension on day 3 was not prognostically reliable after therapeutic induced mild hypothermia for comatose cardiac arrest survivors. None of the patients who lost pupillary or corneal reflexes on day 3 or developed myoclonus status epilepticus recovered awareness.

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Baclofen toxicity can be a cause of profound coma with brainstem dysfunction mimicking brain death, and is mainly a clinical diagnosis. Measuring plasma levels is not always possible and may be misleading. Imaging results are usually normal. Electroencephalography may show a pattern of burst suppression. At present no effective specific therapy is available. However, as demonstrated in our case, the prognosis can be good even in severe cases, provided it is recognized early enough, and appropriate supportive measures are instituted.

This is the first observational study to prospectively collect waveform data for 30 minutes after the declaration of death. A future larger study may support initial data suggesting that circulatory function does not resume after more than 89 seconds of absence. Furthermore, persistence of cardiac electrical activity with the documented absence of circulation may not be relevant to declaration of death.