To study the modified transnasal endoscopic Lothrop procedure (frontal drillout) in an appropriate animal model.Design: Pre-and postoperative three-dimensional (3D) CT scan, direct examination, and histologic study of the frontal sinuses of six cats undergoing frontal drillout.Setting: University animal facility. Interventions:The cat has become a well-established animal model for frontal sinus surgery. In his early reports on anterior osteoplastic frontal sinus obliteration, William Montgomery described his early clinical results, as well as animal studies. He performed this operation in cats and killed them after 6 months, at which time he examined their sinuses and also obtained histologic and serial sections for examination and review. Donald and Fenton performed further studies using the cat model of the frontal sinus. In this study, six cats whose frontal sinuses had been assessed for size and patency by 3D CT scan underwent a modified Lothrop procedure. Three-dimensional CT was undertaken 6 months later, after which the animals were killed and the sinus cavities were opened and examined.Outcome measures: Quantitative evaluation of sinus patency measured on 3D CT scans and on direct visualization, and histologic examination of sinus mucosa.Results: All cats had widely patent sinuses, and histologic study revealed normal mucosa at 6 months. There were no complications.Conclusions: In the feline model, the modified Lothrop procedure resulted in a frontonasal communication that remained patent during the study period.
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