Objectives: The aim of the study was to evaluate the safety and effectiveness of cosmetic products containing two derivatives of vitamin K on skin with vascular problems. Materials and methods: The study was conducted in two groups, 24 people, and the other included 22 participants, mean age 50. The participants applied creams twice a day for a period of 4 weeks. Creams were applied on the right half of the face-concentration of 0.5% and 0.1%-on the left. The participants completed a questionnaire and a measurement was performed using standardized equipment Multi Probe Adapter (MPA) Courage-Khazaka and VISIA Canfield. Results: Application creams with MQ and Epoxy MQ derivatives at a concentration of 0.1% and 0.5% had the effect of reducing redness of the skin at a comparable level. All of formulations did not contribute to decrease melanin level. The hydration was increased after application MQ (0.1% and 0.5%) adequately 14% and 13% in about 60% participants. The elasticity was significantly improved in all groups. Conclusion: Derivatives of vitamin K such as Epoxy MQ and MQ used in 0.1% and 0.5% give comparable results reducing redness of the skin. The improvement of erythema was more significant with 0.1% concentration (MQ and Epoxy MQ).
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