Essentials:• Cadherin-6 function in thrombus formation was investigated in vivo using two murine models of thrombosis. • Blocking or deleting cadherin-6 significantly delayed time to occlusion • Human platelets express cadherin-6, but murine platelets do not.
Abstract
BackgroundPlatelet adhesion is the critical process mediating stable thrombus formation. Previous reports of cadherin-6 on human platelets have demonstrated its role in platelet aggregation and thrombus formation.
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