Reinhart Koselleck project). Boris Bouazza-Arostegui was supported by the NeuroCure Cluster of Excellence with a NeuroCure PhD Fellowship. We are grateful to Berit Söhl-Kielczynski, Bettina Brokowski, Katja Pötschke, Sabine Lenz and Heike Lerch for excellent technical support and to Dr. Melissa Herman for her comments and helpful discussion. We thank the services of the Charité Viral core facility for virus production and characterization. We also thank the services of Advanced Medical Bioimaging Core Facility (AMBIO), Nikon imaging core facilities at the Charité Campus Mitte

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