Background and Aims Balloon angioplasty (BA) without the use of stents has unsatisfactory results, which may cast doubt on its expediency. At the same time, BA is a very expensive treatment method. We conducted a comprehensive comparative analysis of the native arteriovenous fistula (AVF) patency rates in hemodialysis patients with central venous stenosis (CVS) after endovascular BA and «open» palliative surgery. Method A retrospective study included 80 patients with confirmed central vein stenosis: subclavian, brachiocephalic veins, vena cava inferior, or multiple lesions. The main group included 39 patients who underwent percutaneous balloon angioplasty. The control group included 41 patients who did not have balloon angioplasty for various reasons. In this patients we performed only «open» palliative interventions: thrombectomy, proximalization of arteriovenous anastomosis, AVF blood flow reduction. Results Functional primary patency (the time interval between the start of AVF using and the first intervention) did not differ: groups were comparable in time of stenosis manifestation (fig. 1A). Primary patency (the time interval between the first and second interventions) after BA was statistically significantly better than in the main group (fig. 1B), but difference was minimal: median survival in the study group of 8 months [95% CI 6; 10] vs. - 6 months [95% CI 4.9; 7.1]. There was the strong negative correlation between the primary patency and functional primary patency in the main group (r = –0.627 [95%CI –0.787; –0.388], p <0.0001) but not in the control group (r = 0.049 [95%CI –0.262; –0.351], p = 0.7599). Thus, the later manifestation of CVS related with lower effectiveness of BA. The functional secondary patency (total duration of AVF use) in the main group was significantly better: median survival was 47 months [95% CI 40.9; 53.1] vs. 34 months [95% CI 29.8; 38.2] as well as secondary patency (the time interval between the first intervention and the complete cessation of AVF use): median survival was 16 months [95% CI 12.5; 19.5] vs. 7 months [95% CI 4.9; 9.1] (fig. 1 C and D). The occlusion-free period from the moment of starting the AVF use (functional primary assisted patency – fig. 1E) was higher in the main group, but difference was minimal: median survival was 39 months [95% CI 36.5; 41.5] vs. 32 months [95% CI 27.5; 36.5], as well as occlusion-free period from the moment of the first surgical intervention (primary assisted patency – fig. 1F) median survival was 9 months [95% CI 7; 11], in the control group - 7 months [95% CI 5.6; 8.4]. The need for open interventions was lower in the main group: 0.374 [95% CI 0.24; 0.556] and 2.451 [95% CI 1.1963; 3.023] per 10 patient-months, incidence rate ratio (IRR)= 0.153 [95% CI 0.095; 0.237], р<0.0001; as well as overall need for interventions: 1.511 [95% CI 1.225; 1.843] and 2.451 [95% CI 1.963; 3.023] per 10 patient-months, IRR 0.617 [95% CI 0.461; 0.825] p=0.0011. The value of AVF volume blood flow had a strong negative correlation with the primary patency in both groups (r = –0.529, p =0.0027; r = –0.419, p =0.0101). Conclusion 1. Central vein stenosis is inevitably leads to loss of vascular access on the ipsilateral side. 2. Balloon angioplasty allows to extend the period of AVF use but it is not a radical treatment method of CVS. 3. The results of balloon angioplasty are significantly affected by the length of the period from the start of AVF use to the CVS manifestation. 4. Multiple repeated BA are apparently justified in patients for whom the possibility of creating a new vascular access is doubtful. 4. The AVF volume blood flow is an important factor determining the severity of CVS clinical manifestations and the need for repeated surgical interventions.
Background and Aims to analyze the results of surgical correction of native arteriovenous fistula (AVF) aneurysms in hemodialysis patients. Method A retrospective observational study included 158 patients who underwent various surgical interventions. 87 patients (55.1%) underwent pre-emptive surgeries. 71 patients (44.9%) underwent surgeries after AVF thrombosis («on demand» surgery). In the presence of high-flow AVF or in a case of high risk of fistula vein rupture, aneurysmorrhaphy was performed, which was supplemented by transposition of the reconstructed vein – fig. 1. In a case of paraanastomotic stenosis of the vein, aneurysmorrhaphy was enhanced by arteriovenous anastomosis proximalization. In a case of local proximal or distal stenosis of the functional segment of the vein, aneurysmorrhaphy was supplemented with stenosis plastic using the wall of the resected aneurysm. In a case of prolonged proximal stenosis or totally thrombosed proximal aneurysm, the fistula blood flow was switched to v. basilica with its transposition. In the case of a totally thrombosed distal aneurysm, it was excised and proximal AVF was created. Results In the case of pre-emptive surgeries, secondary patency was 69% [95% CI 44.9; 84.2] after 4.8 years (maximum follow-up). In the case of on-demand surgeries the secondary patency was 45.6% [95% CI 23.6; 65.2] after 4.3 years (maximum follow-up) – fig. 2. HR (log rank test) pre-emptive vs. on demand surgeries 0.296 [95% CI 0.147; 0.592], inverse HR = 3.381 [95% CI 1.674; 6.827], p = 0.0002. The risk AVF function loss was lower in patients who received pre-emptive surgeries compared with patients who received on-demand surgery: 2.642 [95% CI 1.406; 4.519] versus 6.268 [95% CI 3.927; 9.49] per 100 patient-years, incidence rate ratio (IRR) = 0.422 [95% CI 0.207; 0.834] (inverse estimate IRR=2.372 [95% CI 1.2; 4.842]), p = 0.0127. The need for CVC was also lower in patients who received pre-emptive surgeries: 1.728 [95% CI 1.38; 2.136] versus 2.821 [95% CI 2.292; 3.434] per 10 patient-years, IRR=0.6125 [95% CI 0.4576; 0.8185] (inverse estimate IRR= 1.633 [95% CI 1.222; 2.185]), p = 0.0009. Moreover, the number of operations was significantly higher in patients who underwent pre-emptive surgeries: 4.207 [95% CI 3.654; 4.821] versus 2.963 [95% CI 2.421; 3.59] per 10 patient-years, IRR=1.42 [95% CI 1.124; 1.802] (inverse estimate IRR= 0.704 [95% CI 0.555; 0.89]), p=0.0031. In almost all cases, fistula vein aneurism has been associated with various hemodynamic disorders. The median volume blood flow Qa was 2.9 [interquartile range - IQR 1.9; 3.8] l/min., (minimum. 1 l/min., max. 4.5 l/min.). Reconstruction in most cases led to significant change in Qa (p<0.0001). After reconstruction, the Qa median was 1.8 [IQR 1.6; 2.1] l/min. (minimum 1.4 l/min., max. 2.1 l/min). It is noteworthy that in patients with low Qa values, Qa increased slightly, and at high values, it decreased significantly. However, additional methods of blood flow reducing were not used. The median of the Qa difference was -1.2 [IQR -1.9; -0.2] l/min. (minimum -2.7 l/min, max. 1 l/min.). Conclusion The indication for surgical treatment is not just aneurism, but its complications, the high risk of complications development or a combined pathology. Preventive surgical interventions can significantly extend the AVF patency and reduce the need for central venous catheters, however, this is achieved by significantly increasing the number of surgeries. The concept of routine monitoring of a normally functioning AVF by a surgeon should replace the concept of on-demand surgery in case of AVF thrombosis or development of other serious complications.
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