Highlights d H 2 O 2 generation is mediated by interaction of Nox4 with p22 phox -SH3YL1 d SH3YL1-Nox4 regulates pro-inflammatory cytokine production and tubular damage d SH3YL1-Nox4 complex plays an important role in LPSinduced acute kidney injury
Background:The molecular mechanisms underlying the non-genomic activities of testosterone in keratinocytes are unknown. Results: Testosterone stimulates Duox1 activity through GPRC6A leading to cell death in skin keratinocyte. Conclusion: These results support an understanding of the molecular mechanism of testosterone-dependent apoptosis through Duox1-induced H 2 O 2 generation. Significance: These results provide a novel signaling cascade of testosterone-mediated redox regulation in keratinocytes.
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