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A tandem inter-and intramolecular Pd-catalyzed amination protocol was studied on 4-chloro-3-iodoquinoline and 3-chloro-4-iodoquinoline with different aminohetarenes. Applying this method, ten novel quinoline derivatives and eight new heterocyclic ring systems were synthesized.

The synthesis of indoloquinolines from bromo‐iodoquinolines by following a two‐step strategy based on a Buchwald—Hartwig amination as a first step followed by an intramolecular Heck‐type reaction to execute the ring closure is described.

Intramolecular Pd-Catalyzed Amination. -A series of novel heterocyclic systems is synthesized using a tandem inter-and intramolecular Pd-catalyzed amination strategy. Intermediates of the reaction, e.g. (III), are isolated after short reaction times. -(BOGANYI*, B.; KAMAN, J.; J. Heterocycl. Chem. 46 (2009) 1, 33-38; Inst. Chem., Eoetvoes Lorand Univ., H-1117 Budapest, Hung.; Eng.) -H. Haber 32-148