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ObjectiveTo empirically test if apathy and impulse control disorders (ICDs) represent independent, opposite ends of a motivational spectrum.MethodsIn this single-center, cross-sectional study, we obtained retrospective demographics and clinical data for 887 patients with idiopathic Parkinson's disease (PD) seen at a tertiary care center. Mood and motivation disturbances were classified using recommended cutoff scores from self-report measures of apathy, ICD, anxiety, and depression.ResultsPrevalence rates included 29.0% of PD patients with depression, 40.7% with anxiety, 41.3% with apathy, 27.6% with ICDs, and 17.0% with both apathy and ICD. The majority (61.6%) of people reporting clinically significant ICDs also reported clinically significant apathy and more than a third of patients with apathy (41.3%) also reported elevated ICD symptoms. Anxiety and depression were highest in patients with both apathy and one or more ICD. Dopamine agonist use was higher in people with only ICD compared to people with only apathy. Mood significantly interacted with demographic variables to predict motivational disturbances.ConclusionsMotivational disturbances are common comorbid conditions in patients with PD. Additionally, these complex behavioral syndromes interact with mood in clinically important ways that may influence the design of future clinical trials and the development of novel therapies. This study challenges the concept of apathy and ICD in PD as opposite ends of a spectrum.

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Objective. To examine the relationship between respiratory functioning and neuropsychological performance, mood, and frontal-lobe-mediated behaviors in ALS patients. Methods. Forty-four patients with probable or definite ALS (El Escorial criteria) completed comprehensive pulmonary and neuropsychological assessments as part of their baseline neurological evaluation. Based on their full vital respiratory capacity, 24 and 20 patients were classified as having impaired or intact respiration, respectively. Results. Comparable demographic characteristics, neuropsychological performance, and self-reported mood symptoms were found between ALS patients with intact versus impaired respiration. However, more respiratory-impaired patients were reported by their caregivers as having clinically significant impairments in frontal-lobe-mediated behaviors. Nevertheless, declines in behavior were evidenced from pre- to post-ALS symptom onset for both respiratory groups, and exploratory analyses revealed greater executive functioning deficits in patients with bulbar versus limb onset as well as respiratory-impaired patients not receiving pulmonary interventions versus those utilizing such interventions at the time of testing. Conclusions. Results suggest that the respiratory insufficiency of ALS patients may potentially produce irreversible deficits in executive functioning; yet once treated, impairments in more basic cognitive abilities may be less evident.

PD patients were slower to complete the OTDL-R, but only less accurate on the telephone use subtest. Poor performance on the telephone use subtest may be related to motor severity, while poor performance on the financial management subtest was related to attention and working memory. Overall, the findings warrant future investigation to determine the validity and reliability of the OTDL-R in PD.

The Rey 15-Item Memory Test (Rey-15) is a standard instrument frequently employed to assess suspect effort/motivation in English-speaking populations. The objective of the current study was to examine the influence of socio-demographic variables on this measure and provide normative data for use with Spanish speakers. The performance of 130 primarily Spanish-speaking, cognitively intact, older adults (ages 50-69) on six Rey-15 scoring systems and six embedded measures of suboptimal performance was examined. Approximately 8% of the sample scored below the recommended cut-off of 9 on the Rey-15. The lowest recall score of 6 was also the minimum score obtained on the recognition trial. Additionally, scores on the alternative Rey-15 scoring methods and the embedded measures of suboptimal performance were lower in comparison to the normative data presently utilized with English speakers, yet comparable across the examined measures. Basic mental status and education level were significant predictors of Rey-15 performance; however, results indicate that these variables may share a close relationship with socio-demographic characteristics such as acculturation level and years of U.S. residency. Preliminary normative data on the Rey-15 for primarily Spanish-speaking older adults, stratified by education, is provided in conjunction with a recommendation for the use of the recognition trial when interpreting results.

The current findings generally support the use of the TOMM with US primarily Spanish speaking patients diagnosed with TBI. However, caution is recommended when utilizing this measure with individuals having minimal levels of education. Future research with a larger sample and a non-neurological age- and education-matched sample should investigate lower cut-off scores for use with such patients.