The sleep macroarchitecture of 10 outpatients with obsessive-compulsive disorder (OCD) was compared to a group of symptomatic, unmedicated outpatients with nonpsychotic major depressive disorder (MOO) (n = 10). No group main effects were observed. Gender by group interactions were observed on the amount of wakefilness and total sleep period. Male patients with M D D had the highest amount of wakefilness, whereas female patients with OCD showed the least amount of wakefilness. Of the REM sleep parameters, only the duration of the individual REM periods showed between-group dsfferences, interacting with gender. Gender main effects were also obtained on the amount of Stage 1 sleep, which was lower among females. R E M latency did not diflerentiate the groups. These findings suggest that selected sleep EEG parameters may diflerentiate patients with M D D f r o m those with OCD, but that these effects are moderated by gender. Depression 2:297-302 (1 99411 995). 0 1995 Wiley-Liss, Znc.
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