The aim of the study was to examine the associations between depressive symptoms and smoking, concurrently and prospectively, in adolescents in America, the evaluation of depressive symptoms according to different group's smoking status, and the assessed associations between concurrent depressive level and success in smoking cessation. The participants were 2,735 boys and 2,890 girls from the Add Health data set. The prospective analysis indicated that participants with higher depressive symptoms in Wave I were more likely to start smoking and become regular smokers in Wave II. Moreover, regression analysis found that depressive symptoms in both Waves I and II predicted current smoking status. Findings are discussed within the context of the empirical and theoretical review and implications for social work practice are considered.Adolescence signifies a dynamic period of growth that can be perceived as enjoyable and enriching, tumultuous and challenging, or a combination of both for many adolescents. During this phase of development, adolescents' emotions and behaviors are more susceptible to influence by internal (physical) and external (social and environmental) factors than adults. Therefore, it may be important to examine factors that affect their well-being. Two such factors are smoking and depression.Over the past three decades, considerable numbers of studies have been done on the area of smoking and depression, and some of these studies have examined the