International audienceTitanate nanotubes (Ti-Nts) have proved to be a potential candidate for drug delivery due to their large surface change and higher cellular uptake as a direct consequence of their tubular shape. Ti-Nts were assessed for their safety, their kinetics of cellular uptake on U87-MG cell line and for genistein loading efficiency. No cytotoxic effect was observed under higher empty Ti-Nts concentrations up to 100 mu g mL(-1). The multiwalled tubular morphology was found to be an important parameter promoting high drug loading. The Ti-Nts could achieve higher genistein drug-loading content (25.2%) and entrapment efficiency (51.2%) leading to a controlled drug release as well as a higher cellular uptake of genistein-loaded- Ti-Nts which induces higher cytotoxicity and significant anti-migratory effect on U87-MG human glioblastoma astrocytoma, promising efficient antitumor activity

No abstract

No abstract

Multiwalled carbon nanotubes have been used for the first time as solid-phase extraction sorbents for the extraction of five N-methylcarbamate insecticides (i.e., carbaryl, carbofuran, aminocarb, methiocarb, and zectran) from different surface water samples. An effective and sensitive method was developed by combining solid-phase extraction and liquid chromatography-electrospray ionization-mass spectrometry detection. Important parameters influencing the extraction efficiency such as kind and volume of elute, volume of water samples, and adsorbent mass were optimized. Under the optimized extraction conditions, good linearity was obtained for all carbamates (r 2 [ 0.995) over the range of 0.005-1 mg L -1 . The limits of detection and quantification were 0.01-0.05 and 0.08-0.2 lg L -1 , respectively. The optimized solid-phase extraction procedure was compared in terms of adsorption capacity to C18 silica and activated carbon. The adsorption capacity of multiwalled carbon nanotubes was larger than activated carbon. The proposed method was successfully applied to the analysis of tap and surface waters, and mean recoveries for five carbamates were from 92.2 to 103.9 % with relative standard deviation between 0.4 and 7.0 %.

No abstract