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The efficacy of inoculation theory has been confirmed by decades of empirical research, yet optimizing its effectiveness remains a vibrant line of investigation. The present research turns to psychological reactance theory for a means of enhancing the core mechanisms of inoculation—threat and refutational preemption. Findings from a multisite study indicate reactance enhances key resistance outcomes, including: threat, anger at attack message source, negative cognitions, negative affect, anticipated threat to freedom, anticipated attack message source derogation, perceived threat to freedom, perceived attack message source derogation, and counterarguing. Most importantly, reactance‐enhanced inoculations result in lesser attitude change—the ultimate measure of resistance.

This investigation examined the potential of inoculation to protect young adults' attitudes from pressures to engage in risky behaviors (unprotected sex and binge drinking) as well as inoculation's efficacy in conferring umbrella protection (cross-protection) over related, but experimentally untreated, attitudes. A three-phase experiment was conducted involving 120 participants. The results revealed that inoculation can protect the attitudes of young adults from counterattitudinal pressures to engage in unprotected sex (treated issue) and binge drinking (untreated issue). Practical applications of these findings are explored, including the use of inoculation when designing health messages and more thorough assessments of health campaigns designed to discourage risky behaviors.

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Contemporary inoculation scholarship has focused on the process of resistance to persuasion, and recently begun to examine various incidental effects that may accompany inoculation treatments. This study considers how talk fits within both of these areas, not only as a byproduct of inoculation, but also as a potentially important contributor to the process of resistance. Results indicate inoculation not only enhances talk about the target issue, but such talk appears to bolsters resistance to subsequent counterattitudinal messages.

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