Analytical difficulties involved in the detection of a wide range of suspected polar and nonpolar drugs in botanical matrices have been solved by adopting a multipronged approach. Preliminary screening of Chinese herbal medications can be accomplished by a combination of thin-layer chromatography and gas chromatography/mass spectrometry and/or the employment of liquid chromatography/mass spectrometry as a probe introduction technique.
The electron ionization (El) and chemical ionization (CI) mass spectra of 12 representative testosterone esters were examined to explore the various analytical options available for identification and confirmation of the esters. Using El, a number of fragment ions indicated the identification of the testosterone moiety, but structural confirmation of the individual esters often required the observance of the molecular ion at very low relative abundance ratios. The acceptable analytical method involved CI/tandem mass spectrometry based on the production of the 2 generic product ions derived from the protonated molecule ion.
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