<p><em>Latar belakang: </em><em>Pemeriksaan radiologi merupakan komponen penting dalam diagnosis penyakit paru. Karena gejalanya sangat mirip dibutuhkan pemeriksaan dengan resolusi spasial tinggi sehingga memberikan informasi anatomi dan struktur yang jelas dalam menentukan diagnosis. Pemeriksaan radionuklir adalah suatu pemeriksaan yang menggunakan sumber radiasi terbuka yang berasal dari inti radionuklida buatan untuk mempelajari perubahan fisiologis dan biokimia sehingga dapat digunakan untuk tujuan diagnosis, terapi, dan penelitian, seperti pemeriksaan skintigrafi dan positron emission tomography (PET). Pemeriksaan radionuklir yang akan di bahas adalah PET/CT, ventilasi skintigrafi, perfusi skintigrafi dan pefusi ventilasi skintigrafi. Kegunaan radionuklir pada bagian paru adalah pada penyakit infeksi paru, fisiologi paru untuk menilai perfusi dan difusi paru pada beberapa penyakit, dan pada kanker paru untuk melakukan diagnosis, menentukan staging, menilai fungsi paru sebelum dan sesudah reseksi, optimalisasi radioterapi dan prognosis kanker paru.</em><em>Kesimpulan: </em><em>Pemilihan modalitas pemeriksaan radionuklir yang tepat bisa memberikan gambaran fungsi paru yang akurat dalam menegakkan diagnosis penyakit paru dan mengurangi paparan radionuklida sehingga luaran pengobatan pasien lebih baik. </em></p>
Pulmonary embolism (PE) is a pulmonary emergency that is quite common with various clinical manifestations, from asymptomatic to life-threatening. The incidence of pulmonary embolism is reported to be 1 per 1000 population, with 50,000 deaths per year. Making the diagnosis is difficult because the symptoms vary widely in each patient. Management of acute pulmonary embolism is carried out with a systematic approach involving early intervention, patient risk stratification, selection of therapy, and determination of the length of treatment.
Background: Treatment given for COVID-19 includes the provision of antiviral, anti-inflammatory, immunomodulatory, anticoagulant, and treatment of comorbidities and complications. The success of treatment in COVID-19 patients does not only depend on the drug given but is also influenced by clinical manifestations, clinical phase, and the presence or absence of complications and comorbidities. This study aims to assess the relationship between initial CT values, inflammatory markers, and symptom onset on treatment outcomes for COVID-19 patients at Dr. M. Djamil General Hospital Padang. Methods: This study is an observational analytic study with a retrospective cohort approach in confirmed COVID-19 patients treated at Dr. M. Djamil General Hospital Padang between 1st January – and 31st May 2021. The sample is the population that meets the inclusion criteria; confirmed COVID-19 from the results of RT PCR/TCM SARS-CoV-2, aged > 18 years, including the clinical degree of moderate, severe, critical illness. Exclusion criteria were patients with incomplete medical record data. Univariate analysis is intended to describe each research variable so that the distribution and percentage of each variable are presented in tabular form. Bivariate analysis using Chi-Square statistical test to see the relationship between variables. Results: COVID-19 patients being treated at Dr. M. Djamil General Hospital Padang were mostly in the age group above 50 years, namely 59.6%, and the female sex was treated more than the male, namely 55.5%. The moderate clinical grade is the highest proportion of hospitalized patients, namely 64.3%, followed by critical clinical 30.0% and severe clinical 5.6%. There is no relationship between the initial CT value and the outcome of COVID-19 patients. There is a relationship between IL-6 levels (initial) with the outcome of Covid-19 patients at Dr. M. Djamil General Hospital Padang. There is no relationship between the onset of clinical symptoms and the outcome of Covid-19 patients at Dr. M. Djamil General Hospital Padang. Conclusion: There is a relationship between IL-6 levels (initial) with patient outcomes, need for oxygen therapy, ferritin levels with the incidence of sepsis, initial albumin levels with initial D-Dimer levels, and IL-6 levels with D-dimers in COVID-19 patients at Dr. M. Djamil General Hospital Padang.
Background: Elevated IL-6 levels have been found in COVID-19 patients and are associated with a poor prognosis. According to COVID-19 management guidelines, several types of corticosteroids can be used as therapy modalities for COVID-19 patients, including dexamethasone, methylprednisolone, and hydrocortisone. The purpose of this study was to examine how dexamethasone administration affected changes in IL-6 levels in confirmed COVID-19 patients at RSUP Dr. M. Djamil Padang.Methods: This was a retrospective cohort study with a sample of all COVID-19 patients who met the inclusion and exclusion criteria and were treated in the COVID-19 isolation ward at RSUP Dr. M. Djamil Padang. The study began in June 2021 and concluded in July 2022. The data was analyzed both descriptively and analytically. The distribution of frequencies and proportions of each variable was included in the univariate analysis. Bivariate analysis employs data-scale-appropriate statistical tests such as the T-test to determine the relationship between independent and dependent variables.Results: The characteristic of the patients were mostly 18-49 years old (37.22%), female (55.67%), of severe clinical degree (49.44%), had no comorbidities (52.78%) and the majority (77.78%) received dexamethasone in the recommended dose (1 x 6 mg). The study's findings revealed that there was no difference in IL-6 values before and after dexamethasone administration in patients with moderate clinical degrees, but there were differences in IL-6 values before and after dexamethasone administration in patients with severe and critical clinical degrees.Conclusion: The IL-6 level has significantly decreased following dexamethasone administration. Dexamethasone administration causes significant changes in IL-6 values in severe and critical degrees but not in moderate clinical degree.
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