The Mote Ocean Technology Club, a new outreach program at Mote Marine Laboratory in Sarasota, Florida, implemented state-of-the-art technology to engage 12 high school students and four teachers during a semester-long afterschool STEM program. Club activities were broad and interdisciplinary, but the primary goal was to build inexpensive sensors and disseminate data streams to the Gulf of Mexico Coastal Ocean Observing System (GCOOS)emulating the activities of many ocean-observing labs around the world. This article details club activities, provides links to the online curriculum, summarizes successes, challenges and recommendations for similar (or smaller) classroom-based efforts, and describes curriculum plans for the next phase of the club.
Modeling the expectations of detection rate for all birth defects based on characteristics of prenatal care delivery in California, the reported detection rates and the logistics and practicalities of testing lead to the conclusion that second trimester screening i;preferable.Cost per birth defect detected is lowest and detection rates are comparable with second trimester screening using multiple serum markers as compared to ultrasound with or without serum markers in the first trimester.MTHFR mutation and a NOS3 polymorphism influence blwd pressure characteristics in preeclam sia S isk kin-Mashiah' A. ~ellicena' L.A. ~e f l e r ' C.E. ~empfer'. A.R. GrefxP2. 1Dept. Ob/Gyn and 2~;man and ~o l e h a r ~enetics: Baylor College of Medicine, Houston. TX.Pathways involving nitric oxide (NO) and homocystine have been implicated in preeclampsia. A bi-allelic polymorphism within intron 4 (1-4) of the endothelial NO synthase gene (NOS3) and a missense mutation (C677T) in the methylenetetrahydrofolate reductase gene (MTHFR) have been independently associated with this disease. We have established an association between a NOS3 I-4 A allele and our preeclamptic women. In this study we evaluated the same women for an association with the MTHFR mutation. We also studied the combined effect of the NOS3 1-4 polymorphism and the MTHFR mutation on the clinical phenotype.54 preeclamptic women (PET) and 37 control women (CTRL) were genotyped. Genotyping was performed by PCR (1-4) or PCR-RFLP analysis (MTHFR). PCR products were scored on a 1.5% OJOS3) and 3% (MTHFR) agarose gel. Women with at least one NOS3 1-4 A allele were combined for analysis otherwise women were scored as B. MTHFR scoring was either C (wildtype) or T (heterozygous). No woman homozygous for the MTHFR mutation was identified.38.9% of PET women and 43.2% of CTRL women were MTHFR-T (p.05). Mean gestational age at admission was the same for both groups. 9 women with PET were scored as AIT. These women had higher systolic blood pressure on admission, after adjusting for gestational age, compared to PET women scored as BIC ( y . 0 5 , ANCOVA). Women with PET scored as N C or BIT had systolic blood pressure in between that observed among compound heterozygous women and those with wild type alleles at both loci (figure).In this preliminq study, MTHFR C677T mutation was not associated with preeclampsia. Among women with preeclampsia, the compound heterozygous genotype, might be predictive of a more severe clinical course.
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