In recent years, large amounts of peptides have been purified and characterized from food protein hydrolysates. Many of these peptides have been demonstrated to be of potential application as health-improving ingredients against plenty of disease conditions, such as cancer, inflammation, and cardiovascular disease. The real efficacy of functional application of these peptides depends on their stability, transport, and bioavailability in target tissues, which in turn depends on the peptides characteristics. Therefore, the characteristic-function parameters are crucial for peptides using as functional agents. This review article intends to summarize the effects of peptide characteristics, including molecular weight, charge and hydrophobicity, on their stability, intestinal transport, and in vitro bioavailability.
BackgroundHighly automated cage-rearing systems are becoming increasingly popular in China. However, a high stocking density can cause oxidative stress and decrease broiler performance. The tryptophan (TRP) derivative 5-hydroxytryptophan (5-HT) has been shown to preserve membrane fluidity in birds suffering from oxidative stress. Therefore, this experiment was conducted to determine the effects of dietary TRP supplementation on performance, breast meat quality and oxidative stress in broilers reared in cages with a high or low stocking density.MethodsFemale Arbor Acres broilers (25-d-old, n = 144) were randomly allocated to 1 of 4 treatments. The birds were fed a diet based on corn, soybean meal, cottonseed meal and corn gluten meal containing either 0.18 or 0.27% TRP and were housed with stocking densities of 11 or 15.4 birds/m2 in a 2 × 2 factorial experiment. Broiler performance was evaluated from d 25 to 42. Eight birds from each treatment were slaughtered on d 42 and plasma and breast muscle samples were collected to measure biochemical indices.ResultsA higher stocking density tended to be associated with reduced weight gain (P < 0.10), and significantly increased plasma glutamic-pyruvic transaminase (GPT) activity (P < 0.001). Increased dietary TRP significantly reduced the activities of lactic dehydrogenase and GPT while increasing total cholesterol in the plasma (P < 0.01), reducing drip loss of breast muscle (P < 0.10) and improving feed efficiency (P < 0.10).ConclusionsAn increase in dietary TRP, 1.5-fold higher than the standard supplementation level, can alleviate oxidative stress as well as improve welfare and feed efficiency in broilers reared in cages with a high stocking density.
As a new type of methane control agent, natural plant extract has been widely studied in recent years, but in vivo studies are few. This study was to investigate the effects of the dietary supplementation of 2 different polyphenols on the methane (CH4) emission and digestion metabolism in sheep. Ten healthy crossbred sheep (Dorper ♂ × small-tailed Han ♀; BW 60.0 ± 1.73 kg) were used in a change-over design. The sheep were fed the following 3 diets in the present study: the basal diet (CON) with no supplementation; the basal diet supplemented with 2 g mulberry leaf flavonoid (MLF) per day per sheep; the basal diet supplemented with 0.25 g resveratrol (RES) per day per sheep. Both MLF and RES reduced CH4 emission scaled to metabolic weight per kilogram of DMI and CO2 output scaled to metabolic weight, but the effect of RES was significant (P < 0.05). Both MLF and RES significantly improved apparent digestibility of DM, OM, NDF, ADF, and nitrogen, but the effect of RES was significant (P < 0.05). Both MLF and RES significantly improved ME (P < 0.05) and reduced energy losses in CH4 emission (P > 0.05). In conclusion, MLF and RES can improve the digestibility of nutrients, the utilization of nutrients and energy, and reduce CH4 emission, but they are not conducive to nitrogen retention.
The motion of solid particles and the ''fish-hook'' phenomenon in an industrial classifying hydrocyclone of body diameter 355 mm is studied by a computational fluid dynamics model. In the model, the turbulent flow of gas and liquid is modeled using the Reynolds Stress Model, and the interface between the liquid and air core is modeled using the volume of fluid multiphase model. The outcomes are then applied in the simulation of particle flow described by the stochastic Lagrangian model. The results are analyzed in terms of velocity and force field in the cyclone. It is shown that the pressure gradient force plays an important role in particle separation, and it balances the centrifugal force on particles in the radial direction in hydrocyclones. As particle size decreases, the effect of drag force whose direction varies increases sharply. As a result, particles have an apparent fluctuating velocity. Some particles pass the locus of zero vertical velocity (LZVV) and join the upward flow and have a certain moving orbit. The moving orbit of particles in the upward flow becomes wider as their size decreases. When the size is below a critical value, the moving orbit is even beyond the LZVV. Some fine particles would recircuit between the downward and upward flows, resulting in a relatively high separation efficiency and the ''fish-hook'' effect. Numerical experiments were also extended to study the effects of cyclone size and liquid viscosity. The results suggest that the mechanisms identified are valid, although they are quantitatively different.
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