Enterobacterales
,
Pseudomonas aeruginosa
, and
Acinetobacter baumannii
are the most common Gram-negative bacilli to cause nosocomial infections throughout the world. Due to their large public health and societal implications, carbapenem-resistant
A. baumannii
(CRAB), carbapenem-resistant
P. aeruginosa
(CRPA), and carbapenem-resistant and third-generation-cephalosporin-resistant
Enterobacteriaceae
were regarded by the World Health Organization (WHO) as a global priority for investment in new drugs in 2017.
In recent years, the detection rate of carbapenem-resistant
K. pneumoniae
has increased and represents a major threat to clinical anti-infective therapy. Compared with KPC-type carbapenemases and NDM-type metallo-β-lactamases, OXA-48 family carbapenemases are another important resistance mechanism mediating bacterial resistance to carbapenems.
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