Health-related quality of life (HRQoL) is a broad concept reflecting a patient's general subjective perception of the effect of an illness or intervention on physical, psychological and social aspects of their daily life. HRQoL among patients infected with HIV has become an important indicator of impact of disease and treatment outcomes. A cross-sectional survey was carried out at Chitungwiza Central Hospital, Zimbabwe, to assess HRQoL in patients with HIV/AIDS receiving antiretroviral therapy (ART), using two validated instruments. The HIV/AIDS-targeted quality of life (HAT-QoL) and EuroQoL Five-dimensions-Three-level (EQ-5D-3L) instruments were used to assess HRQoL. Internal consistency reliability and convergent validity of the two instruments were also evaluated. For construct validity, the relationships between HRQoL scores and socio-economic and HIV/AIDS-related characteristics were explored. The median scores for the HAT-QoL dimensions ranged from 33.3 (financial worries) to 100 (HIV mastery). A considerably low HAT-QoL dimension score of 50.0 was observed for sexual function. There were ceiling effects for all HAT-QoL dimension scores except for financial worries and disclosure worries. Floor effects were observed for financial worries and sexual function. The median of the EQ-5D-3L index and visual analogue scale (VAS) was 0.81 and 79.0, respectively. There were no floor or ceiling effects for both the EQ-5D-3L index and VAS. The overall scale Cronbach's alpha was 0.83 for HAT-Qol and 0.67 for EQ-5D-3L. HAT-QoL demonstrated good convergent validity with EQ-5D index (0.58) and VAS (0.40). A higher level of HRQoL was positively and significantly related to income, education and employment. The patients' self-reported HRQoL was generally satisfactory in all the HAT-QoL dimensions as well as the two components on the EQ-5D-3L instrument. The two instruments demonstrated good measurement properties in HIV/AIDS patients receiving ART and have potential for use, alongside biomarkers, in monitoring outcomes of interventions.

Coronavirus disease 2019 (COVID-19) is an infectious disease that has become a global pandemic. COVID-19 is spreading in Africa, and Zimbabwe has not been spared. The cases in Zimbabwe are mainly from imported cases due to high volume of travellers from the COVID-19 hotspots. In Zimbabwe, local transmission is also anticipated due to inter- and intracity travelling. Frontline health workers are at risk of infection due to contact with infected people as they discharge their duties. In this setting, the risk to community pharmacists and pharmacy personnel is poorly understood and characterised. This paper looked at the risks of infection that are peculiar to community pharmacy personnel and suggested some recommendations to reduce the risk to COVID-19 infection.

Emergency contraceptives play a major role in preventing unwanted pregnancy. The use of emergency contraceptives is characterized by myths and lack of knowledge by both health professionals and users. The main objective of this paper is to summarize the clinical pharmacology of hormonal methods of emergency contraception. A literature review was done to describe in detail the mechanism of action, efficacy, pharmacokinetics, safety profile, and drug interactions of hormonal emergency contraceptive pills. This information is useful to healthcare professionals and users to fully understand how hormonal emergency contraceptive methods work.

Very few low‐income countries have developed national plans to achieve the viral hepatitis elimination targets set in the World Health Organization (WHO) strategy. We reviewed the policy environment, strategies and challenges on the fight against viral hepatitis in Zimbabwe. The review focussed on the Ministry of Health and Child Care (MoHCC) policy documents, strategic plans and reports. We performed key informant interviews to enhance evidence generated from the document review. Twelve documents were reviewed and interviews with 10 key informants were completed. The MoHCC established a technical working group to work towards elimination of viral hepatitis. The technical working group drafted a strategic plan for elimination of viral hepatitis; however, it is still awaiting implementation. Key strategies that are working well include screening of donated blood for transfusion, safe injection practices and hepatitis B virus (HBV) three‐dose vaccination. Current challenges in the drive towards elimination of viral hepatitis include poor to non‐existent surveillance systems, lack of epidemiological data, absence of the HBV vaccine birth dose and lack of systematic screening and treatment services for viral hepatitis. In conclusion, despite political will demonstrated towards achieving viral hepatitis elimination, substantial investment and work are required to implement the strategic plan and realize significant success.

The coronavirus 2019 (COVID-19) pandemic has led to national lockdowns in multiple states. The education system, including pharmacy education, has been negatively affected by the subsequent closure of universities. Many institutions have resorted to virtual learning, which work best in settings with fast, stable internet connections and where electricity is readily available. In resource-limited settings, popular virtual interaction platforms like Zoom may not work, and educators have to devise novel ways to continue teaching. The University of Zimbabwe used innovative mobile phone-based processes to ensure continuation of the final-year pharmacy students’ honours research projects, supervision, and timely submission. This facilitated rapid communication between students and professors and allowed effective guidance for the students’ research process. All students completed their projects; 13 out of 16 submitted their write-ups within the deadline; all students passed, 69% scored an upper second (2.1) grade or better, indicating the high quality of the majority of the research projects.

towards improved OS when compared with the other TKIs: afatinib (HR 0.80, 95% CrI 0.52-1.23), erlotinib (HR 0.82, 95% CrI 0.44-1.53), gefitinib (HR 0.76, 95% CrI 0.58-1.00), osimertinib (HR 0.76, 95% CrI 0.52-1.13), and icotinib (HR 0.64, 95% CrI 0.34-1.22); a statistically significantly improved PFS compared with erlotinib (HR 0.45, 95% CrI 0.22-0.90) and gefitinib (HR 0.51, 95% CrI 0.39-0.66); a trend towards improved PFS for afatinib (HR 0.67, 95% CrI 0.44-1.02), osimertinib (HR 0.93, 95% CrI 0.64-1.35) and icotinib (HR 0.59, 95% CrI 0.31-1.14). Conclusions: Overall, this NMA found that dacomitinib had a consistent trend towards improved OS and PFS when compared with other TKIs for first-line treating locally advanced or metastatic EGFR mutation positive NSCLC among Asian populations.

To ameliorate the impact of brain drain on quality of education at the University of Zimbabwe, the Health Education Advanced Leadership in Zimbabwe (HEALZ) programme was implemented in 2012. The authors present a retrospective narrative review of the pharmacy educators’ activities under the programme, and the impact on pharmacy education. Five pharmacy educators were enrolled into the one-year programme between 2016 and 2020. The programme consisted of three intensive one-week face-to-face sessions focused on health professions education. In between the sessions, the educators conducted needs’ assessments to establish gaps in pharmacy training and developed curricula in the areas of herbal medicine, snakebites, drug-herb interactions, oncology, and health economics. Thereafter, they delivered seven conference abstracts and nine continuing professional development training sessions. The pharmacy educators are now working on transferring the HEALZ programme to the two new pharmacy training institutions, to strengthen the pharmacy education workforce across the country.

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