Cataract is considered a major cause of visual impairment in diabetic patients as the incidence and progression of cataract is elevated in patients with diabetes mellitus. The pathogenesis of diabetic cataract development is still not fully understood. Due to increasing numbers of type 1 and type 2 diabetics worldwide, the incidence of diabetic cataracts steadily rises. Even though cataract surgery, the most common ophthalmic procedure worldwide, is an effective cure, the elucidation of patho- mechanisms to delay or prevent the development of cataract in diabetic patients remains a challenge. Furthermore, patients with diabetes mellitus have higher complication rates from cataract surgery. Both diabetes and cataract pose an enormous health and economic burden, particularly in developing countries, where diabetes treatment is insufficient and cataract surgery often inaccessible. Hence the objective of the study was to assess the antioxidant levels and calcium levels in different stages of cataract. Our study showed a significant reduction in lens antioxidant activity with significantly increased calcium levels in mature stage of cataract, suggesting decreased antioxidant activity plays an important role in diabetic cataract by causing deposition of calcium in lens. DOI: http://dx.doi.org/10.3126/ijls.v6i1.5290
Aim and objective: To seamlessly integrate the biochemical knowledge and clinical application of liver function tests (LFTs) for easy reference. Background: The LFTs are one of the key investigations done during patient care. Several times during the patient workup, the complete panel of tests is done which is not necessary and adds extra financial burden on the patients. Medical students and young doctors should be aware of the clear indication of tests, to diagnose the condition and treat it accordingly. Healthcare professionals must use these test results in the proper perspective of patient history and physical examination to arrive at the correct diagnosis.
Conclusion and clinical significance:This article highlights the main parameters tested in LFTs and their interpretation in a convenient and easily accessible format.
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