clinicaltrials.gov Identifier: NCT00206141.

clinicaltrials.gov Identifier: NCT00119652.

No abstract

No abstract

This study evaluated the efficacy and tolerability of quetiapine monotherapy for depressive episodes in patients with bipolar I or II disorder (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) who were randomized to 8 weeks of double-blind treatment with quetiapine (300 or 600 mg/d; once daily, evening dosing) or placebo. Patients were assessed weekly using the Montgomery-Asberg Depression Rating Scale (MADRS) and Hamilton Depression Rating Scale (HAM-D). The primary end point was change in MADRS total score from baseline to Week 8 (analysis of covariance/last-observation-carried-forward analysis). Of 509 patients randomized, 59% completed the study. Improvements from baseline in mean MADRS total scores were significantly greater with quetiapine 300 and 600 mg/d than with placebo from first evaluation (Week 1) through Week 8 (both P

In patients stabilized on quetiapine plus lithium or divalproex, continued treatment was associated with a significant risk reduction in the time to recurrence of any mood event compared with placebo and lithium or divalproex.

No abstract

Tomographic imaging techniques were applied to two crosshole data sets to determine the velocity structures and the reliability and resolution of the algorithms on real data. The experiments were carried out at the Retsoff salt mine in New York and at the underground radioactive waste study site at the Stripa mine facility in Sweden. The traveltimes at Restoff were high quality and were obtained over raypaths of up to 500 m in length. The structure was quite complicated with velocity contrasts up to 50 percent. The Stripa site was in granitic rock with velocity contrasts of only a few percent. The dimensions of the experiment were small with maximum ray lengths of just over 10 m. The data at this site were collected with very high accuracy, source and receiver locations were measured to better than 1.0 mm, and traveltimes were read to 0.001 ms. A number of algorithms similar to the algebraic reconstruction techniques (ART) used in medical imaging have been applied to the data. Some modifications of the algorithms, such as the application of weighting schemes, damping parameters, and curved raypaths, were performed. The resulting velocity fields were compared to the known fields and with each other to determine an optimal method. The algorithms were found to be a rapid, reliable means of reconstructing the slowness field of real data. Low‐velocity zones were recovered with accuracy in location and value. It was also found that great care was necessary in application of the techniques to ensure that proper damping parameters are used and the proper number of iterations taken; otherwise poor reconstructions will result.