Introduction: Dysregulation in purine metabolism is strongly implicated in diabetic complications. Purine metabolism is dependent on xanthine dehydrogenase (XDH), which under stress is converted to xanthine oxidase (XO), and can generate reactive oxygen species (ROS). Therefore, we hypothesize that targeted inhibition of XDH will normalize purine metabolism in the diabetic regenerative environment, decrease ROS accumulation, and accelerate wound healing.
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