Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives are
prevalent in many synthetic intermediates,
pharmaceuticals, and organic materials. Herein, we develop a Mn-catalyzed
electrochemical radical cascade cyclization reaction that uses electricity
as the primary energy input to promote the reaction, leading to a
series of benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives under exogenous-oxidant-free conditions.
It is worth noting that this electrochemical method can not only realize
the synthesis of benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives but also provides a new strategy for
generating alkyl radicals from alkylboronic acids.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.