Five cholate-based nicotinamide adenine dinucleotide hydrogen (NADH) models have been designed and synthesized. The asymmetric reduction of methyl benzoylformate by the NADH models was investigated under the catalyst of Mg 2+ as complex center. The results indicated that these NADH models could reduce α-keto ester to α-hydroxyl ester, possessing the ability of hydride transfer and the low ability of chiral reduction. The enantiomeric excess value of the reduced product was up to 26%.
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