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Our study aims to assess the clinical implication of RAV/rBSA ratio in PRT as a predictor for attained renal function at 1 year post‐transplantation and its association with surgical complications. A retrospective cohort was performed for PRT cases from January 2000 to December 2015 in our institution. Extracted clinical information includes the recipient's demographics, donor type, renal allograft characteristics, arterial, venous and ureteral anastomoses, vascular anastomosis time while kidney off ice, overall operative time, and estimated blood loss. The RAV/rBSA was extrapolated and assessed for its association with renal graft function attained in 1 year post‐transplantation and surgical complications within 30‐day post‐transplantation. A total of 324 PRTs cases were analyzed. The cohort consisted of 187 (52.4%) male and 137 (42.3%) female recipients, with 152 (46.9%) living donor and 172 (53.1%) deceased donor renal transplants, and an overall median age of 155.26 months (IQR 76.70‐186.98) at time of renal transplantation. The receiver operating characteristic identified that a RAV/rBSA ratio of 135 was the optimal cutoff in determining the renal graft function outcome. Univariate and multivariate analyses revealed the relative OR for RAV/rBSA ≥ 135 ratio in predicting an eGFR ≥ 90 attained within 1 year post‐transplant was highest among younger pediatric recipients (<142.5 months) of deceased kidney donors (OR = 11.143, 95% CI = 3.156‐39.34). Conversely, Kaplan‐Meier analysis revealed that RAV/rBSA ratio ≥ 135 is associated with lower odds of having eGFR <60 (OR = 0.417, 95% CI = 0.203‐0.856). The RAV/rBSA ratio was not associated nor predictive of transplant‐related surgical complications. Our study determined that the RAV/rBSA ratio is predictive of renal graft function at 1‐year PRT, but not associated with any increased surgical complications.

Neuropathic pain is the unpleasant sensation due to lesion of nerves. It is common in patients with diabetes as fluctuations in blood glucose take a toll on the nervous system. Furthermore, high doses of metformin for the long duration in patients, with type 2 diabetes are found to interfere with the normal metabolism of the vitamin B12 in body that leads to its deficiency. Vitamin B12 is a water soluble vitamin found in our body responsible for the methylation, thus has a role in the myelin sheath and DNA synthesis. Deficiency of vitamin B12 has debilitating effect on the nerves which results in neuropathy. Various studies have been carried out to study whether Vitamin B12 has an effect on the nervous regeneration or can its use improve the diabetic or metformin induced neuropathy? In this paper, up-to-date evidence for effect of vitamin b12 supplementation on diabetic peripheral neuropathy has been studied and evaluated.

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