AN X-linked degenerative retino-choroidal disease, hereditary retinoschisis, has been identified in the last 10 years. In milder cases the disease takes the form of radial macular degeneration, but in severe cases a grey sheet-like veil is attached to the detachment in the retinal vasculature, especially in the lower temporal quadrant. In differential diagnosis, according to Ricci (1960), a dominant hereditary hyaloid-retinal degeneration (Wagner, 1938) and a recessive hereditary hyaloid-tapeto-retinal degeneration (Favre, 1958) should be borne in mind. Genealogical tables covering several generations have been described by Sorsby, Klein, Gann, and Siggins (1951), Levy (1952), Jager (1953), Balian and Falls (1960), and Gieser and Falls (1961). The last described a 13-yearold girl-possibly a latent carrier-with cystic (perhaps traumatic) macular degeneration. Rieger (1941) described a girl in whom the pathological picture was reminiscent of retinoschisis, but gave no genealogical or genetic
It is essential to know all the details of the normal electroretinogram (ERG) when using electroretinography for clinical purposes. The investigations made hitherto on the normal ERG in man, however, have not been aimed at determining whether there is any difference dependent on sex.Karpe's normal material (1945) consisted of 74 eyes in 48 patients between the ages of 11 and 50 years of which 37 were young men between 21 and 35 years. Only six of the cases, however, were women. The mean b-potential for these women's eyes was 0.40 mV as compared with 0.36 mV for all the eyes in the series. Another normal material of patients above 50 years of age assembled by Karpe, Rickenbach and Tllomasson (1950) comprised 33 eyes in 19 men and 41 eyes in 21 women. Here, too, the mean b-potential differed between the men and the women as follows: men 0.30 k 0.066 m V * * ) ; women 0.34 f 0.080* * ) mV. The difference between these bpotential values is ,0.04 f 0.016* * * ) and is therefore probably significant.Both these investigations thus suggest that there is normal-*) Received Nov. 6th 1950. *') standard deviation o = I/ 2 (Pi M)2
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