Activity. -The synthesis of optically active anellated azabicyclo[3.3.1]nonanes (IV) and (XI) is readily achieved by halogen/ lithium exchange and subsequent double cyclization of bis(α-hetarylmethyl)amino esters (III) and (X), resp., which in turn are obtained on various ways from o-bromohetarylmethyl bromides (I) and optically active amino acid esters (II). The cyclization is influenced by the steric bulk of the reactants and in some cases only the monocyclization products (VI)/(VII) or (XII) are achieved. The double cyclization products possess interesting inhibiting activity against reverse transcriptase and DNA polymerase of HIV-1. -(FALTZ, H.; BENDER, C.; WOEHRL, B. M.; VOGEL-BACHMAYR, K.; HUEBSCHER, U.; RAMADAN, K.; LIEBSCHER*, J.; Eur.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.