Aims and Objectives: To find out the presence of Sst I polymorphism in APOC3 gene in patients of diabetes mellitus with Hypertriglyceridemia. To find out the correlation between serum triglyceride levels and Sst I polymorphism. To find out the correlation between serum levels of various lipoprotein fractions and Sst I polymorphism. Methods: The present study is a hospital-based observational case-control study, carried out in 300 patients of diabetes mellitus. Of these 300 subjects, 150 were hypertriglyceridemic and served as cases, while the other 150 who were normotriglyceridemic served as controls. PCR for APOC3 gene was done in all subjects. Result: In a total of 300 subjects, 26.33% (n=79) had shown presence of Sst I polymorphism in APOC3 gene. Polymorphic gene was present in 35.33% of cases while only in 17.33% of controls. The mean cholesterol level in the group with Sst I polymorphism was significantly higher than in group with S1 allele only. The mean triglyceride in the group with S1 allele only was 152.97±45.86 mg/dl and that in the group with Sst I polymorphism was 212.84±103.07 mg/dl, and this increased mean triglyceride level was statistically significant as determined by chi-square test. Mean HDL level was also significantly lower in the group with Sst I polymorphism as compared to that with S1 allele only. The odds ratio of developing hypertriglyceridemia was 2.6059 in those carrying the Sst I polymorphism as compared to those with only S1 allele. The association between increasing levels of triglyceride and the increasing percentage of Sst I polymorphism was also statistically significant. Conclusion: This is the first study from North-East India to determine the Sst I polymorphism in APOC3 gene, and demonstrate a clear association between the polymorphism and serum levels of various lipoprotein fractions, including triglycerides. A prospective study comprising of a wide population group will help us in forming a definite conclusion. Disclosure B.C. Kalita: None. R.K. Kotokey: None. S. Das: None. A. Chakravorty: None. H. Soni: None.
Background: As of 2019, the highest prevalence of human immunodeficiency virus (HIV) in India is seen in the Northeastern states. Endocrine and metabolic disturbances can occur in HIV infection. Thyroid dysfunction is one of the common endocrinopathies. In HIV infection, thyroid function abnormalities are seen in about 4–35% of adult patients. Thyroid function abnormalities range from overt hypothyroidism, subclinical hypothyroidism, and sick euthyroid syndrome to overt hyperthyroidism. Among them, subclinical hypothyroidism is the commonest abnormality. To our knowledge, there have been no studies from Northeastern India done in this regard. Aims and objectives: To study the thyroid function in newly diagnosed cases of HIV infection attending anti-retroviral therapy (ART) center, Assam Medical College. To estimate the prevalence and types of thyroid dysfunction in newly diagnosed HIV-infected individuals. To study thyroid dysfunctions with respect to age, sex, and cluster of differentiation (CD) 4 count. Materials and methods: Hospital-based observational study was done at a tertiary care centre of upper Assam on newly diagnosed HIV-positive patients who were not started on antiretroviral therapy and who attended the ART centre, Assam Medical College during the period of our study. History, examinations and laboratory investigations, including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and CD4 count, are done in all such patients, and only those who fulfilled the inclusion and exclusion criteria of our study are taken as study participants, and their findings tabulated. Results and observations: A total of 95 newly diagnosed HIV-positive patients fulfilling the inclusion and exclusion criteria of our study were taken. In our study, a total of 36.84% of the patients had thyroid dysfunction. We got subclinical hypothyroidism, overt hypothyroidism, sick euthyroid syndrome, and overt hyperthyroidism as the types of thyroid dysfunction. Among all the types of thyroid dysfunction, subclinical hypothyroidism was the commonest abnormality in our study. Under sick euthyroid syndrome, we got only low FT3 as the biochemical abnormality. Thyroid dysfunctions were more common in females (42.3%) than males (35.8%) and were more common in the age group of 30–39 years. In the present study, among patients with thyroid dysfunction, it was seen that 51.43% of the patients had a CD4 cell count in the range 101–200 cells/mm3 , whereas only 11.43% of patients had a CD4 cell count in the range <50 cells/mm3 and no patient had a CD4 cell count >500 cells/mm3 . Conclusion: In our study, we found that thyroid dysfunctions were common in newly diagnosed HIV-positive patients, the prevalence of which was much higher in the general population. Thyroid dysfunction was present in all the stages of the HIV disease.
80 panic disorder patients were diagnosed with electroencephalography (EEG). The study was electroencephalographic (EEG) changes of Panic Disorder patients in West Uttar Pradesh,India. The objectives 1) To examine the EEG of Panic Disorder patients. 2)To explore the clinical features for the diagnosis of panic disorder and their association with EEG. A large group of patients having panic disorder showed abnormal EEG associated with their clinical features. The pathophysiology behind is not clarified. The study was interpreted with 14 (17.5%) panic disorder patients and EEG abnormalities of 80 patients conflict with 13 symptoms in DSM-IV. The patients were assessed with Logistic regression analysis.EEG was selected as the dependent variable and age, sex, and with or without 13 symptoms as independent variables. The panic disorder patients showed abnormal EEG alpha frequency with repeatedly slow theta frequency. Nausea or abdominal distress (43.4% vs 67.7%, p = 0.01); derealization or depersonalization (37.7 %vs82.4%, p = 0.005); or paresthesias (7.5%vs47.1%, p = 0.001) were extracted by multivariate analysis as factors related to EEG abnormalities. The study indicated that physiological predispositions are closely related to panic disorder.
Erythema nodosum leprosum (ENL) is a debilitating inflammatory complication of leprosy characterised by inflammatory cutaneous nodule with or without ulceration. An intriguing feature of ENL is its exquisite sensitivity to treatment with the immunomodulatory drug thalidomide, which was discovered serendipitously in the early 1960s. Thalidomide is now the treatment of choice for ENL. However, being an immunosuppressant, thalidomide has the potential of making the patient vulnerable to infections. 1 Tuberculosis (TB) and leprosy are two ancient pathogens, which have been identified as infecting humans since thousands of years. It has been shown from archaeological evidence, post-mortem findings, and retrospective analysis of leprosy institutions' data that there is a highly observed incidence of concomitant infection with leprosy and TB. However, reports of concomitant infection in modern literature remain scarce. Estimation of the annual new case detection rate (ANCDR) in India where both TB (ANCDR 181 per 100,000 in 2011). 2 and leprosy (ANCDR 10.35 per 100,000 in 2011). 3 remain endemic, suggest that only 0.019 cases of concomitant infection per 100,000 population are detected per year. CASE SUMMARYA 30-year-old male was admitted in the Department of Medicine, Assam Medical College and Hospital in September 2015 with complaints of multiple painful swellings over armpits and groins for 20 days along with fever. He had received MDT for leprosy the previous year and was currently on corticosteroids and thalidomide for recurrent ENL reaction. FNAC of the swollen lymph nodes proved them to be of tuberculous origin. The patient was put on ATT under DOTS and he improved eventually.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.