An efficient methodology has been developed for the synthesis of tetra-and pentasubstituted pyrroles via oxidative self-dimerization of N-propargylamines catalyzed by silver benzoate in the presence of K 2 S 2 O 8 in good yields. The protocol provides a simple route for the synthesis of both tetra-and pentasubstituted pyrroles with two carbonyl groups in the side chain. The methodology can be extended toward the synthesis of pyrrolo- [3,4-d]pyridazine.
An efficient methodology has been developed for the synthesis of both di-and trisubstituted thiazol-2(3H)-ones from Npropargylamines and silver(I) trifluoromethanethiolate (AgSCF 3 ) in good yields. The reaction proceeds via [3,3]-sigmatropic rearrangement/5-exodig cyclization of N-propargylamines. The starting material can be easily prepared from the A 3 -coupling reaction of amines, aldehydes, and alkynes. The methodology can be extended for the synthesis of thiozole-2(3H)thione derivatives, and photophysical properties have been studied for some synthesized compounds.
A simple methodology has been developed for the synthesis of substituted 9H-dibenzo[3,4:6,7]-cyclohepta[1,2-a]naphthalenes from phenylacetaldehydes and ortho-alkynyl benzyl alcohols in presence of Lewis acid in moderate to good yields within a...
A metal-free Lewis acid-initiated protocol for the synthesis
of
highly substituted 3-(dihydrofuran-3(2H)-ylidene)isobenzofuran-1(3H)-imines from 2-(4-hydroxybut-1-yn-1-yl)benzamides and
aldehydes has been demonstrated. The reaction involves the initial
formation of dihydrofuranylidene carbocation via a
Prins cyclization reaction using BF3·OEt2, followed by intramolecular cyclization to produce 3-(dihydrofuran-3(2H)-ylidene)isobenzofuran-1(3H)-imines up
to E/Z = 6:1 with moderate to good
yields. The methodology can also be used for the synthesis of 3-(dihydro-2H-pyran-3(4H)-ylidene)-isobenzofuran-1(3H)-imines. The strategy leads to the formation of two C–O
bonds and one C–C bond with two different heterocycles connected
by a tetra-substituted double bond. Post synthetic application of
the reaction was extended for the synthesis of furanylidene isobenzofuranones
in excellent yields.
Indium(III)
chloride can be efficiently used for the synthesis
of 4-vinylpyrrolidine from N-tethered alkyne-alkenol in good yields.
The reaction is highly stereo- and regioselective.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.