Colon cancer is one of the major causes of cancer mortality worldwide. However, the underlying mechanism and therapeutic targets of colon cancer have not yet been fully elucidated. In the present study, we demonstrate that citron rho-interacting, serine/threonine kinase 21 (CIT) promotes the growth of human colon cancer cells. CIT is overexpressed in human colon cancer tissues and cell lines. High expression of CIT predicts poor survival for patients with colon cancer. In colon cancer cells, CIT knockdown represses cellular proliferation and colony formation. Our in vivo xenograft experiments showed that CIT knockdown reduces the growth rate of colon cancer cells and the final tumor weight. We found that CIT knockdown induces cell cycle arrest and apoptosis in colon cancer cells. Further microarray and bioinformatics analyses indicated that CIT regulates the p53 signaling pathway, which may account for the effects of CIT on colon cancer cells. Taken together, our findings provide evidence that CIT may promote the development of colon cancer, at least in part, through the p53 signaling pathway. Therefore, CIT may be a potential therapeutic target for colon cancer treatment.

The traditional meetings, incentives, conferences, and exhibitions (MICE) industry has been hit hard by social distancing regulations introduced to combat the COVID-19 pandemic, with concerns about pandemic risks and personal hygiene increasing the demand for online MICE technology. With the introduction of innovative new technologies to the MICE industry, it is important to study the psychology of online MICE attendees, particularly the factors affecting their behavioral intention to adopt online MICE technology during the pandemic. This study investigates the attitudes toward attending online MICE since the start of the epidemic based on the health belief model (HBM) and innovation diffusion theory (IDT). A total of 439 valid questionnaires were collected in China and used for structural equation modeling. The results show that the perceived safety threat, the comparative advantage, trialability, and outcome expectations positively impact the attendees' attitudes. Moreover, this study finds that attitude completely mediates the impact of perceived safety threat, comparative advantages, trialability, and outcome expectation on behavioral intention to attend online MICE events. These findings theoretically enrich the understanding of online MICE technology, the HBM, and the IDT and offer managerial implications for MICE organizers and exhibitors.

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