Hypothyroidism is emerging to be one of the most common endocrinological disorders worldwide which when left undetected or untreated leads to severe complications. However, clinical manifestations vary from serious symptoms to certain non-specific symptoms like fatigue, weight gain, depression or aches and pains. It occurs more in women and a positive family history of thyroid diseases where traced frequently. Thyroid stimulating hormone is highly sensitive to thyroid dysfunction and commonly used to evaluate thyroid disorders. The standard treatment of hypothyroidism restores the thyroid function by daily use of the synthetic hormone tablets. Homoeopathic medicine plays a significant role in management of thyroid disorder. A case reported in the OPD of National Homoeopathy Research Institute in Mental Health, Kottayam with reports of raised levels of thyroid stimulating hormone showed its reduction after administration of Homoeopathic medicine. This is documentary evidence showing that an underactive thyroid gland is effectively acted upon by Homoeopathic interventions to bring about desired effects.