Silk-based nanoparticles have been exhibiting an increasing potential for use as drug delivery systems due to their great versatility. To extend applications of silk sericin in nanomedicine and improve the performance of silk-based nanoparticles in drug delivery, a facile two-step cross-linking is attempted, for the first time, to fabricate surface charge-reversal silk sericin-based nanoparticles (SSC@NPs) by introducing chitosan into silk sericin. The results suggest stable SSC@NPs are formed with a negative surface charge in a neutral environment. Under mildly acidic conditions, however, surface charge of SSC@NPs undergoes a negative-to-positive conversion. It proves that pH can regulate surface charge of SSC@NPs. It is the increased amino/carboxyl ratio in SSC@NPs that explains the underlying mechanism of the charge conversion property of SSC@NPs. Furthermore, the positively charged SSC@NPs triggered by tumor acidic microenvironment (pH 6.0) result in a 6.0fold higher cellular uptake than the negatively charged counterparts at pH 7.4. In addition, an anticancer drug doxorubicin (DOX) is readily loaded into SSC@NPs and released in a pH-dependent manner. This work provides a simple method to fabricate smart pH-responsive nanoparticles for anticancer drug delivery.

We report low temperature magnetotransport measurements on a high mobility (µ = 325 000 cm 2 /V sec) 2D electron system on a H-terminated Si(111) surface. We observe the integral quantum Hall effect at all filling factors ν ≤ 6 and find that ν = 2 develops in an unusually narrow temperature range. An extended, exclusively even numerator, fractional quantum Hall hierarchy occurs surrounding ν = 3/2, consistent with two-fold valley-degenerate composite fermions (CFs). We determine activation energies and estimate the CF mass.

We investigate a silicon single-electron transistor (SET) in a metal-oxide-semiconductor (MOS) structure by applying a magnetic field perpendicular to the sample surface. The quantum dot is defined electrostatically in a point contact channel and by the potential barriers from negatively charged interface traps. The magnetic field dependence of the excitation spectrum is primarily driven by the Zeeman effect. In the two-electron singlet-triplet (ST) transition, electron-electron Coulomb interaction plays a significant role. The evolution of Coulomb blockade peaks with magnetic field B is also owing to the Zeeman splitting with no obvious orbital effect up to 9 T. The filling pattern shows an alternate spin-up-spin-down sequence. The amplitude spectroscopy allows for the observation of the spin blockade effect, where the two-electron system forms a singlet state at low fields, and the spin polarized injection from the lead reduces the tunneling conductance by a factor of 8. At a higher magnetic field, due to the ST transition, the spin blockade effect is lifted and the conductance is fully recovered.