Graphical AbstractMulti-strain tropical Bacillus spp. as a potential probiotic biocontrol agent for large-scale enhancement of mariculture water quality.
V. harveyi
as a dominant pathogen has become a major hazard in mariculture development and seafood safety, and biocontrol of this pathogen using antagonistic probiotic agents is a long-standing biological challenge.
P. piscicida
WCPW15003 has promise as a novel, safe, and effective bioagent for specifically inhibiting dominant pathogenic
V. harveyi
and protects mariculture animals from infection by this pathogen by moderating the host immune response, which is heavily driven by multi-costimulatory pathways in a coculture of WCPW15003 and
V. harveyi
. This work identified a direction for comprehensively elucidating the molecular mechanism of WCPW15003 antagonism against the dominant pathogen in mariculture using modern molecular biology techniques and provided deep insights into the advantages and potential of this antagonistic probiotic against
V. harveyi
for the construction of an environmentally friendly, recirculating mariculture system.
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