A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-ketoesters, and alkynes under mild reaction conditions.

No abstract

A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic b-ketoesters, and alkynes under mild reaction conditions. Figure 1. Electrophilic trifluoromethylthiolating reagents.

N-Trifluoromethylthiosaccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluoromethylthiolating Reagent. -N-Trifluoromethylthiosaccharin (III) is a highly stable crystalline compound and a powerful trifluoromethylthiolating reagent. It allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, carbonyl compounds, electron-rich arenes, and alkynes under mild reaction conditions. -(XU, C.; MA, B.; SHEN*, Q.; Angew. Chem., Int. Ed. 53 (2014) 35, 9316-9320, http://dx.