<b><i>Introduction:</i></b> Obesity is a major risk factor for metabolic disorders in children. Therefore, it is particularly important to study the abnormal regulation of circulating miR-24-3p in obese children and its predictive value for metabolic syndrome. <b><i>Methods:</i></b> Serum samples were obtained from children with obesity (<i>n</i> = 45), obese children with metabolic syndrome (<i>n</i> = 52), and healthy controls (<i>n</i> = 50). The expression levels of miR-24-3p were detected by reverse transcription quantitative PCR. The ROC curve was used to evaluate the diagnostic value of miR-24-3p. Pearson’s correlation analysis was performed to evaluate the relationship between serum miR-24-3p and different clinical parameters. Logistic regression analysis was used to evaluate the relationship between miR-24-3p and obesity with metabolic syndrome in children. <b><i>Results:</i></b> The expression of miR-24-3p was the highest in obese children with metabolic syndrome. ROC results showed that miR-24-3p had the ability to distinguish healthy individuals from obese children (area under the curve [AUC] = 0.951) and can predict the occurrence of metabolic syndrome for obese children (AUC = 0.890). The expression level of miR-24-3p was positively correlated with body mass index (<i>r</i> = 0.817, <i>p</i> < 0.001), fasting blood glucose (<i>r</i> = 0.798, <i>p</i> < 0.001), triglycerides (<i>r</i> = 0.773, <i>p</i> < 0.001), systolic blood pressure (<i>r</i> = 0.746, <i>p</i> < 0.001), and diastolic blood pressure (<i>r</i> = 0.623, <i>p</i> < 0.001), respectively. Logistic regression analysis showed that miR-24-3p was an independent influence factor for the occurrence of metabolic syndrome in obese children. <b><i>Discussion/Conclusion:</i></b> MiR-24-3p is a potential noninvasive marker for children with obesity and has predictive value for the occurrence of metabolic syndrome.
Introduction: Early onset sepsis (EOS) remains a potentially fatal newborn condition, especially in very preterm infants. Data on the pathogen distribution and antibiotic susceptibility patterns of EOS among very preterm infants are scarce but essential for the choice of empirical antibiotic administration. We sought to assess the epidemiologic characteristics and
Objectives
We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia (BPD) and focus on discussing its relationship with the duration of initial invasive mechanical ventilation (IMV) in very preterm neonates less than 32 weeks of gestational age (GA).
Methods
We performed a prospective cohort study involving infants born at 23–31 weeks of GA who were admitted to 47 different neonatal intensive care unit (NICU) hospitals in China from January 2018 to December 2021. Patient data were obtained from the Sina-northern Neonatal Network (SNN) Database.
Results
We identified 6538 very preterm infants, of whom 49.5% (3236/6538) received initial IMV support, and 12.6% (823/6538) were diagnosed with moderate-to-severe BPD symptoms. The median duration of initial IMV in the moderate-to-severe BPD group was 26 (17–41) days, while in the no or mild BPD group, it was 6 (3–10) days. The incidence rate of moderate-to-severe BPD and the median duration of initial IMV were quite different across different GAs. Multivariable logistic regression analysis showed that the onset of moderate-to-severe BPD was significantly associated with the duration of initial IMV [adjusted odds ratio (AOR): 1.97; 95% confidence interval (CI): 1.10–2.67], late-onset neonatal sepsis (LONS), and patent ductus arteriosus (PDA).
Conclusion
In this multicenter cohort study, the duration of initial IMV was still relatively long in very premature infants, and the longer duration of initial IMV accounts for the increased risk of moderate-to-severe BPD.
In this paper is proposed a dislocation emission mechanism for microcrack initiation at the tip of a finite rigid conducting line in a piezoelectric solid. When a finite rigid conducting line is embedded in a piezoelectric matrix, because of the highly concentrated stress and electric displacement fields at its tips, dislocations of one sign are driven away from the tip, while the stationary dislocations of the opposite sign are left behind. As a result, a micro Zener-Stroh crack is initiated at each tip for the in-plane case, and two microcracks at each tip for the antiplane case. We obtain analytical solutions of both in-plane and anti-plane extension forces for microcracks initiated at the tip of a finite rigid conducting line. By obtaining the stress and electric displacement fields at the tip under nonzero net Burgers vectors, we observe two critical crack lengths. We find that the inplane and anti-plane critical extension forces for a finite rigid conducting line are related to those for a conventional crack in the same piezoelectric materials.
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