The
ruthenium complex (8-(2-diphenylphosphinoethyl)aminotrihydroquinolinyl)(carbonyl)(hydrido)ruthenium
chloride exhibited extremely high efficiency toward the coupling cyclization
of γ-amino alcohols with secondary alcohols. The corresponding
products, pyridine or quinoline derivatives, are obtained in good
to high isolated yields. On comparison with literature catalysts whose
noble-metal loading with respect to γ-amino alcohols reached
0.5–1.0 mol % for Ru and a record lowest of 0.04 mol % for
Ir, the current catalyst achieves the same efficiency with a loading
of 0.025 mol % for Ru. The mechanism of acceptorless dehydrogenative
condensation (ADC) was proposed on the basis of DFT calculations;
in addition, the reactive intermediates were determined by GC-MS,
NMR, and single-crystal X-ray diffraction. The catalytic process is
potentially suitable for industrial applications.
The ruthenium(ii) complex, [fac-PNHN]RuCl2(PPh3) (C), in combination with t-BuOK proved an effective and versatile catalyst allowing aromatic-, aliphatic- and cycloalkyl-containing alcohols to be efficiently converted to their corresponding ketones with high values of TON achievable.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.