We investigated the antiarrhythmic effects of bidisomide (SC-40230), a new class I antiarrhythmic drug, in early-phase ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. The effects of bidisomide were compared with those of mexiletine (MXT) and disopyramide (DSP), established class I antiarrhythmic drugs. Drugs were administered intravenously, 5 min before induction of coronary occlusion. Bidisomide (5 mg/kg) reduced the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to MXT and DSP in rats with ventricular arrhythmias induced by coronary artery occlusion. In rats with ventricular arrhythmias induced by coronary artery reperfusion following a 5-min coronary occlusion, the antiarrhythmic effects of 5 mg/kg of bidisomide were similar to those of the same doses of MXT and DSP. All three drugs significantly slowed the heart rate. Our results suggest that bidisomide may effectively reduce the severity of life-threatening ventricular arrhythmias that occur during acute coronary syndrome.
The failure modes and the shear capacity of concrete beams reinforced with FRP reinforcement were discussed through an experimental investigation, in which continuous FRP rectangular spirals were used for shear reinforcement, while ordinary deformed steel bars are used for longitudinal reinforcement. Six concrete beams reinforced with FRP spirals were tested, the main variables considered were the shear reinforcement ratios, the shear span to depth ratios and the longitudinal reinforcement ratios. Two concrete beams of equal shear capacity which reinforced with continuous steel rectangular spirals were also tested to compare the behavior of concrete beams reinforced with different materials of spirals. All beams were tested as simply supported members subjected to a three-point load, the span of the beams varied in terms of different shear span to depth ratios. The test results show that the shear capacity and shear failure modes are greatly influenced by the shear reinforcement ratios and the shear span to depth ratios, the shear resistance provided by steel spirals is higher than that provided by FRP spirals in the case of equal shear capacity of beams, which is attributed to the differences in material properties and may result in different shear failure types. Based on the experimental program, four mechanical models are derived to give more accurate predictions of the shear capacity of test beams, the calculation results of these models are compared with that of the existing shear formulas or equations for concrete beams reinforced with FRP stirrups or spirals. The rotating-angle softened truss model, the strut-and-tie model, the shear formulas derived from the truss-arch model and Zsutty equations are suggested through comparison.
An experimental program was carried out by the author to investigate the shear behavior of concrete beams reinforced with continuous FRP rectangular spirals, the main variables considered in the test were the shear reinforcement ratio and the shear span to depth ratio and the longitudinal reinforcement ratio. However, the experimental program is inadequate to gain insight into the shear behavior of the members. First, the quantities of test specimens were too small, only six beams were made and tested, the experimental database was so limited that the resultant analytical results and conclusions may not be sound enough. Second, not all the main factors that have influences on the shear behavior of the members have been treated as variables in the experimental program, such as the effective transverse compression stress and the concrete compression strength, the influences of these two factor on the shear behavior of the members were not clear yet through the experimental study. Considering the insufficient information provided by the experimental investigation, the parametric analysis of the shear behavior of the members was carried out, and a revised rotating-angle softened truss model for the shear analysis of the members was proposed as the analytical tool. Based on the proposed model, the influences of various factors on the shear capacity and shear failure modes of the members were discussed, related nonlinear analysis was carried out using the arithmetic of iteration and step approximation, and several FORTRAN codes were written accordingly. Through the experimental study and the parametric analysis, it is indicated that the shear capacity and the shear failure modes of the members are greatly influenced by three major factors, including the shear reinforcement ratio and the shear span to depth ratio and the effective transverse compression stress. The influences of the concrete compression strength and the longitudinal reinforcement ratio on the shear capacity are not noticeable comparatively. The shear capacity is little affected by the shear span to depth ratio in the case of the shear-tension failure, there is no noticeable correlation between longitudinal reinforcement ratio and the shear failure modes.
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