Plant
viral diseases cause tremendous decreases in crop yield and
quality. Natural products have always been a valuable source for lead
discovery in medicinal and agricultural chemistry. A series of pimprinine
alkaloids and their derivatives were prepared and identified by nuclear
magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry
(HR-MS). The antiviral activities of these alkaloids against tobacco
mosaic virus (TMV) were systematically investigated for the first
time. Most of the compounds exhibited higher antiviral activities
than ribavirin. Compounds 5l, 9h, and 10h, which had similar or higher antiviral activities than
ningnanmycin (perhaps the most widely used antiviral agent at present),
emerged as new antiviral pilot compounds. This systematic structure–activity-relationship
research lays the foundation for simplifying the structure of these
alkaloids. The ring-open products, acylhydrazones 9a–9u, were also found to possess good antiviral activities.
Moreover, all the synthesized compounds displayed broad-spectrum fungicidal
activities. This study provides important information for the research
and development of pimprinine alkaloids as novel antiviral agents.
Hydrophilic interaction chromatography (HILIC) strategy is considered as a widely used strategy for efficient glycopeptide enrichment. Here, a novel hydrophilic material (denoted as magCDP@Ada-MSA) was constructed through the host-guest interaction...
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