We present what is to our knowledge the f irst imaging system based on optoelectronic terahertz time-domain spectroscopy. Terahertz time-domain waveforms are downconverted from the terahertz to the kilohertz frequency range, and the waveform for each pixel is frequency analyzed in real time with a digital signal processor to extract compositional information at that point. We demonstrate applications to package inspection and chemical content mapping in biological objects.

We have generated electromagnetic beams from a variety of semiconductors. When a bare semiconductor wafer was illuminated by femtosecond optical pulses, electromagnetic waves radiate from the surface and form collinear diffraction-limited electromagnetic beams in the inward and outward directions. The amplitude and phase of the radiated field depend on carrier mobility, the strength and polarity of the static internal field at the semiconductor surface.

Overcoming immune tolerance of the growth factors associated with tumor growth should be a useful approach to cancer therapy by active immunity. We used vascular endothelial growth factor (VEGF) as a model antigen to explore the feasibility of the immunogene tumor therapy with a vaccine based on a single xenogeneic homologous gene, targeting the growth factors associated with angiogenesis. To test this concept, we constructed a plasmid DNA encoding Xenopus homologous VEGF (XVEGF-p) and control vectors. We found that immunogene tumor therapy with a vaccine based on XVEGF was effective at both protective and therapeutic antitumor immunity in several tumor models in mice. VEGF-specific autoantibodies in sera of mice immunized with XVEGF-p could be found in Western blotting analysis and ELISA assay. The purified immunoglobulins were effective at the inhibition of VEGFmediated endothelial cell proliferation in vitro, and at antitumor activity and the inhibition of angiogenesis by adoptive transfer in vivo. The elevation of VEGF in the sera of the tumor-bearing mice could be abrogated with XVEGF-p immunization. The antitumor activity and production of VEGF-specific autoantibodies, significantly elevated IgG1 and IgG2b, could be abrogated by the depletion of CD4 ؉ T lymphocytes. The observations may provide a vaccine strategy for cancer therapy through the induction of autoimmunity against the growth factors associated with tumor growth in a cross reaction with single xenogeneic homologous gene and may be of importance in the further exploration of the applications of other xenogeneic homologous genes identified in human and other animal genome sequence projects in cancer therapy.

We describe a technique to extract electro-optic Cherenkov radiation from a LiTaO3 crystal into free space. This permits the generation of collimated beams of terahertz radiation into free space and overcomes previous limitations imposed by total internal reflection.

We report a novel technique for the generation of tunable narrow-band submillimeter wave electromagnetic radiation in free space. This is accomplished by mixing two linearly chirped optical pulses with a variable time delay on a biased large aperture GaAs photoconducting antenna. The center frequency of the THz radiation varies linearly with the delay between the two chirped pulses from dc to ∼1 THz.

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When illuminated by ultrashort optical pulses, large aperture planar photoconductors are shown to radiate a directional electromagnetic pulse which can be steered by varying the angle of incidence of the optical beam.

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